| 鼠伤寒患者血清中鼠伤寒杆菌外膜蛋白抗体的分析 |
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| 引用本文： | 李福胜 胡志荣. 鼠伤寒患者血清中鼠伤寒杆菌外膜蛋白抗体的分析[J]. 河南医学研究, 1994, 3(1): 27-29 |
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| 作者姓名： | 李福胜 胡志荣 |
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| 作者单位： | 河南医科大学微生物学与免疫学教研室 |
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| 摘 要： | 本文对鼠伤寒患者抗鼠伤寒杆菌外膜蛋白（ＯＭＰ）的体液免疫应答进行了分析，发现恢复期患者血清中存在高效价的ＯＭＰ抗体，而且以ＩｇＧ型抗体为主（＞１：５１２０）。免疫印迹试验（Ｗｅｓｔｅｒｎｂｌｏｔ）分析恢复期血清识别的主要是３６ＫＤ蛋白带，即微孔蛋白（Ｐｏｒｉｎ）。提示ＯＭＰ有可能用于诊断鼠伤寒杆菌感染及作为保护性抗原制备亚单位疫苗。
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| 关 键 词： | 外膜蛋白，鼠伤寒杆菌，免疫印迹试验 |
ANALYSE OF OMP ANTIBODY IN SERA OF PATIENTS SUFFERED FROM TYPHIMURIUM |
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| Li Fu-sheng Hu Zhi-rong Zhao Feng-lan Hu Jun Xu Yu-mei. ANALYSE OF OMP ANTIBODY IN SERA OF PATIENTS SUFFERED FROM TYPHIMURIUM[J]. Henan Medical Research, 1994, 3(1): 27-29 |
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| Authors: | Li Fu-sheng Hu Zhi-rong Zhao Feng-lan Hu Jun Xu Yu-mei |
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| Abstract: | The studies reported here were undertaken to assess the ability of the outermember protein(OMP)of S.typhimurium to induce a humoral immune response in patients.It has been found that IgG and IgM serum titers of convalescent sera.Much higher than thecontrol serum titers.Sera from patients reacted mainly with a protein of 36 kilodalton(porin)as determined by western blot.These results indicate that OMP antibody may be of diagnos-tic value and porins are the major immune response induced in the infection could be relatedto the protective status. |
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| Keywords: | outer member protein(OMP) salmonella typhimurium western blot |
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