| 正电子药物在肿瘤诊断中的进展 |
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| 引用本文： | 张佳胤,李彪. 正电子药物在肿瘤诊断中的进展[J]. 国际放射医学核医学杂志, 2006, 30(1): 30-35 |
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| 作者姓名： | 张佳胤 李彪 |
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| 作者单位： | 200025 上海, 上海瑞金医院核医学科 |
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| 摘 要： | 正电子发射型体层显像(PET)在肿瘤的早期诊断、分期、良恶性鉴别以及复发监测中有着广泛的应用。18F-氟代脱氧葡萄糖(18F-FDG)是目前最成熟的正电子肿瘤显像剂,但是18F-FDG在部分肿瘤中的显像结果并不理想。11C-甲硫氨酸(11C-MET)、11C-乙酸(11C-acetate)、11C-胆碱(11C-choline)、18F-脱氧胸苷(18F-FLT)等各类非葡萄糖代谢的正电子显像剂逐渐投入临床使用,它们将和18F-FDG互补,提高各种肿瘤诊断的敏感性、特异性和准确率。
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| 关 键 词： | 肿瘤 体层摄影术 发射型计算机 脱氧葡萄糖 |
| 文章编号： | 1673-4114(2006)01-0030-06 |
| 收稿时间： | 2005-12-10 |
| 修稿时间： | 2005-12-10 |
The development of positron emission tomography tracers in the diagnosis of malignant tumors |
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| ZHANG Jia-yin,LI Biao. The development of positron emission tomography tracers in the diagnosis of malignant tumors[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2006, 30(1): 30-35 |
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| Authors: | ZHANG Jia-yin LI Biao |
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| Affiliation: | Department of Nuclear Medicine, Ruijin Hospital, Shanghai 200025, China |
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| Abstract: | Positron emission tomography(PET) is widely used in early diagnosis, staging, post-treatment follow-up of malignant tumors as well as the differentiation between benign and malignant tumor. So far, 18F-fluorodeoxyglucose (18F-FDG) is the most popular and mature PET tracer according to its excellent performance in various types of cancer. But in some kind of cancers, 18F-FDG fails to accurately diagnose them. Now with the clinical application of non-glucose metabolic PET tracers like 11C-methionine (11C-MET), 11C-acetate、11C-choline and 18F-fluorodeoxythymidine(18F-FLT), they complement 18F-FDG in improving the sensitivity, specificity and accuracy of tumor diagnosis. |
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| Keywords: | Tumor Tomography emission-computed Deoxyglucose |
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