O/W型微乳对水难溶性药物增溶作用的研究

目的:考察微乳对不同脂溶性药物的增溶情况.方法:以相图为基础制备聚氧乙烯氢化蓖麻油-乙醇-十四酸异丙酯-水微乳体系及相应的表面活性剂溶液系统,分别用紫外分光光度法测定药物在两种载药体系中的溶解度.结果:吲哚美辛和硝酸咪康唑在微乳及相应的表面活性剂胶束溶液中的溶解度没有显著性差异;而布洛芬在两个体系中存在显著性差异.结论:O/W型微乳和相应表面活性剂溶液对药物的增溶取决于药物在油中的溶解情况,药物的脂溶性越强增溶作用越显著.

Comparison of drug incorporation into non-ionic micellar and O/W microemulsion systems

Objective: To investigate the difference between the uptake of different hydrophobe drugs into the O/W microemulsion systems and micellar solutions. Methods:Based on the phase diagram,the incorporation of 3 poorly water soluble drugs into Cremophor RH-40-alchohol-isopropyl myristate-water microemulsions and Cremophor RH-40 surfactant systems were examined. Results: There was no significant difference between miconazole nitrate and indometacin into the O/W microemulsion systems and micellar preparation.There was,however,a significant increase in the micellar solutions of ibuprofen amount than in the microemulsion systems. Conclusion:Improvement of solubility by O/W microemulsion and micellar system depends on the solubility of the drug in the dispersed oil phase and is significant only for high lipophilic drugs.