| 粘附分子在乳腺癌中的表达 |
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| 引用本文： | 何常,龙义国,方艺.粘附分子在乳腺癌中的表达[J].贵州医药,2000,24(12):710-711. |
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| 作者姓名： | 何常 龙义国 方艺 |
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| 作者单位： | 贵阳医学院病理教研室,550004 |
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| 基金项目： | 贵州省科技厅科研项目，E96-1， |
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| 摘 要： | 目的 探讨粘附分子上皮钙粘素（Ｅ－ｃａｄｈｅｒｉｎ，Ｅ－ＣＤ）、ＣＤ４４Ｈ在乳腺癌组织中的表达及与生物学行为的关系。方法 应用免疫组织学ＳＰ法研究２０例乳腺腺病及４８例乳腺癌组织中Ｅ－ＣＤ、ＣＤ４４Ｈ的表达。结果 乳腺腺病及乳腺癌组织中Ｅ－ＣＤ的阳性表达率分别为９０％（１８／２０例）、４２％（２０／４８例），两者差异有显著意义（Ｐ〈０．０１）；ＣＤ４４Ｈ的阳性表达率分别为２０％（４／２０例）、８１％（３９／４８例），两者差异有显著意义（Ｐ〈０．０１）；同时Ｅ－ＣＤ及ＣＤ４４Ｈ在乳腺癌组织中的表达与其分化程度、浸润深度、淋巴结转移等有相关性（Ｐ〈０．０５／０．０１）。结论 Ｅ－ＣＤ及ＣＤ４４Ｈ参与了肿瘤的发生、发展、浸润及转移。
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| 关 键 词： | 乳腺癌 粘附分子 免疫组织化学 E－CD CD44H |
Expression of adbesion molecules the significance in breast cancer |
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| He Chang,Long yiguo,Fang Yi. Depavtment of Pathology,Guiyang Medical College,Guiyang.Expression of adbesion molecules the significance in breast cancer[J].Guizhou Medical Journal,2000,24(12):710-711. |
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| Authors: | He Chang Long yiguo Fang Yi Depavtment of Pathology Guiyang Medical College Guiyang |
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| Institution: | He Chang,Long yiguo,Fang Yi. Depavtment of Pathology,Guiyang Medical College,Guiyang,550004 |
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| Abstract: | Objective TO study the expression of E-cadherin(E-CD),CD44H and the relationship between their expression and the biological behavior of breast carcinoma. Methods Using immunohistochemistry of SP,20 cases of breast adenosis and 48 cases of breast carcinoma were examined.Results The positive rates of E-CD in breast adenosis and breast carcinoma were 90%, 42%, respectively. The positive rate in adenosis was higher than that of carcinoma(P<0.01);The positive rates of CD44H were 20%, 81%, respectively. The positive rate in adenosis was lower than that of carcinoma(P<0 01),and the expression of E-CD,CD44H in breast carcinoma were related with differentiation, depth of invasive, lymph node metastasis (P<0.01).Conclusion E-CD and CD44H were involved in the tumorigenesis, development, invasion and metastases. |
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| Keywords: | Breast cancerm E-CD CD44H Immunohistochemistr\ |
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