Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS |
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| Authors: | Sébastien Rivière Blandine Denis Marie-Elisabeth Bougnoux Fanny Lanternier Marc Lecuit Olivier Lortholary |
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| Institution: | Service des Maladies Infectieuses et Tropicales, Centre d’Infectiologie Necker – Pasteur, Paris, France; Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France; Université Paris-Descartes, Paris, France; Institut Pasteur, Centre National de Référence Mycoses Invasives et Antifongiques, CNRS URA3012, Paris, France |
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| Abstract: | Abstract. Disseminated histoplasmosis is an emerging infection in patients with cellular immune deficiency in non-endemic countries, caused by the migration from endemic regions and the development of travels. Diagnosis can be challenging in this context because rapid diagnostic tools such as Histoplasma antigen detection or appropriate molecular tools are generally unavailable, serology is often negative in immunosuppressed patients, and isolation of the fungus from cultures often takes several weeks. Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis. |
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