Effect of active immunization with serotonin-protein conjugate on the development of experimental Parkinson's syndrome

Experiments on 5- and 10-month-old rats demonstrate a protective effect of active preimmunization with serotonin-protein conjugate on the development and course of the parkinsonismlike syndrome induced by intranigral injection of 1-methyl-4-phenylpyridinium⁺. The protective effect of antiserotonin antibodies was more pronounced in younger animals. The severity of manifestations of the syndrome may depend on the level of antidopamine autoantibodies. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 392–395, April, 1996