| 四氯化碳性脂肪肝血清游离脂肪酸谱变化 |
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| 引用本文： | 阎明,孟繁立,吕瑞娟,贾晓青,赵宪邨.四氯化碳性脂肪肝血清游离脂肪酸谱变化[J].中国病理生理杂志,2004,20(8):1485-1488. |
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| 作者姓名： | 阎明 孟繁立 吕瑞娟 贾晓青 赵宪邨 |
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| 作者单位： | 山东大学齐鲁医院消化科, 山东 济南 250012 |
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| 基金项目： | 山东省科技厅资助项目 (No.9712 2 6 2 14 ) |
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| 摘 要： | 目的:探讨CCl4性脂肪肝血清游离脂肪酸谱的变化。方法:以40%CCl4腹部皮下注射的方法复制CCl4性脂肪肝大鼠模型。用气相色谱方法测定血清游离脂肪酸谱。结果:CCl4性脂肪肝模型组血清游离脂肪酸谱中多不饱和脂肪酸水平明显低于对照组油酸C18:1,(28.672±7.332/mg.L-1vs41.373±2.180/mg.L-1),亚油酸C18:2(16.739±0.871/mg.L-1vs24.959±5.325/mg.L-1),花生四烯酸C20:4(6.105±2.656/mg.L-1vs9.802±0.779/mg.L-1),P<005],而饱和脂肪酸的水平则显著高于对照组月桂酸C12：0(3.368±0.330/mg.L-1vs2.7420.351/mg.L-1),肉豆蔻酸C14:0(27.1363.158/mg.L-1vs16.152±0.638/mg.L-1),棕榈酸C16:0(51.731±9.561/mg.L-1vs34.522±1.401/mg.L-1),P<005]。结论:CCl4性脂肪肝血清中不饱和脂肪酸水平明显降低,饱和脂肪酸水平显著升高。
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| 关 键 词： | 四氯化碳 脂肪肝 脂肪酸类 非酯化 色谱法 |
| 文章编号： | 1000-4718(2004)08-1485-04 |
| 收稿时间： | 2003-3-19 |
| 修稿时间： | 2003-7-28 |
Alteration of serum free fatty acids during the carbon tetrachloride-induced fatty liver in rats |
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| YAN Ming,MENG Fan-li,LV Rui-juan,JIA Xiao-qing,ZHAO Xian-cun.Alteration of serum free fatty acids during the carbon tetrachloride-induced fatty liver in rats[J].Chinese Journal of Pathophysiology,2004,20(8):1485-1488. |
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| Authors: | YAN Ming MENG Fan-li LV Rui-juan JIA Xiao-qing ZHAO Xian-cun |
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| Institution: | Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China |
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| Abstract: | AIM: To investigate the alteration of serum free fatty acids in the carbon tetrachloride-induced fatty liver. METHODS: Drug-induced fatty liver rat models were built by injection 40% CCl4. Serum free fatty acids were analyzed by gas chromatography. RESULTS: In the composition of serun free fatty acids, polyunsaturated fatty acids , were decreased significantly, but saturated fatty acids increased. CONCLUSION: Serum polyunsaturated fatty acids were decreased and saturated fatty acids increased in the drug-induced fatty liver. |
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| Keywords: | Carbon tetrachloride Fatty liver Fatty acids nonesterified Chromatography |
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