夏天无生物碱对麻醉犬脑循环与下肢循环的作用

本文报告夏天无生物碱可使麻醉犬脑与下肢血流量增加,血管阻力减低(经统计学处理均有显著性差异)、血压轻度下降。提示其有扩张脑血管和下肢血管的作用。并可对抗去甲肾上腺素引起的脑血管与下肢血管的紧张状态。该药不能解除5-羟色胺所产生的脑血管紧张状态。其扩张脑血管作用不被阿托品阻断。

Effects of Alkaloids of Corydalis Decumbers on Cerebral and Peripheral Circulation in Dogs

Effects of the total alkaloids of Corydalis decumbers(TACD)and its principal alkaloid,protopine,on cerebral and peripheral circulation were studied in 75 anesthetized dogs. TACD 1 mg/kg given intra-arterially induced a significant increase of cerebral b1ood flow,a striking reduction of its vascular resistance and a falling of the systemic blood pressure.When the cerebral vessels were in a hypertonic state induced by noradrenaline,intra-arterial injection of TACD could still show the same reactions,but could not affect the vasoconstricting response of serotonin on the cerebral vessels. TACD 5mg/kg given intravenously showed no significant influence on cerebral blood flow and its vascular resistance.For peripheral blood flow,1 mg/kg of TACD administered intra-arterially induced a significant increase of femoral blood flow and a marked decrease of its vascular resistance;but such effects were not recorded in i.v.given TACD 5 mg/kg. Protopine 0.2 mg/kg given intra-arterially produced similar effects both on cerebral and femoral circulation as TACD 1 mg/kg given intra-arterially.Intravenous injection of protopine 2 mg/kg caused an increase of both cerebral and femoral blood flow,a reduction of their vascular resistance and a falling of the systemic blood pressure.These results indicate that TACD and protopine possess the effect of vasodilation on cerebral and peripheral vessels.