肺挫伤患者炎性细胞因子TNF、IL-6的动态变化及其临床意义

目的　探讨血清肿瘤坏死因子 (TNF)、白细胞介素 6(IL 6)在肺挫伤及其继发性肺损伤中所起的作用。方法　严格选择 3 0例肺挫伤患者 ,用ELISA法动态测定TNF、IL 6血清浓度变化 ;合并少量血胸者同时测定胸腔积液TNF、IL 6水平 ;同期选择单纯肋骨骨折及正常人为对照组。结果　肺挫伤患者 ,血清中TNF、IL 6水平明显升高 ;肺挫伤后胸腔积液中TNF、IL 6变化极为显著 ,尤其IL 6的浓度。结论　TNF、IL 6在肺挫伤及其继发性肺损伤中起着重要作用 ;肺挫伤后胸腔积液中TNF、IL 6变化 ,较为可靠地反映了肺组织局部损伤的程度 ,为临床肺挫伤治疗效果的观察提供一个较为客观有效的指标

THE CLINICAL SIGNIFICANCE OF THE DYNAMIC CHANGES OF SERUM CONCENTRATION OF INFLAMMATORY CYTOKINES TNF、AND IL-6 IN PATIENTS WITH PULMONARY CONTUSION

Objective: To evaluate the roles of serum inflammatory cytokines such as Tumor Necrosis Factor(TNF) and interleukin-6 (IL-6) in pulmonary contusion and lung injury related to pulmonary contusion. Methods: 30 patients with pulmonary contusion were accurately selected. The changes of TNF and IL-6 serum level were dynamically observed by enzyme linked immunoabsorbed assay (ELISA). The same markers were tested in pleural effusion of those patients of pulmonary contusion with a little amount of hemothorax. The changes of TNF and IL or in those of health-checking individuals used as control. Results: Compared with the controls, the serum level of TNF and IL-6 were increased significantly in the patients with pulmonary contusion. The similar increases were obvious in pleural effusion of those patients with a little amount of hemothorax. Conclusions: Such inflammatory cytokines as TNF and IL-6 might play important roles in pulmonary contusion; the high level of TNF and IL-6 in pleural effusion truly reflected the degree of lung damage, the levels of TNF and IL-6 concentration in pleural effusion might act as efficacious markers for us to evaluate the treatment of pulmonary contusion and predict its outcome.