| 乳腺典型髓样癌与非典型髓样癌中E-cadherin、CD44v6的表达及意义 |
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| 引用本文： | 李晓鸣,朱任之.乳腺典型髓样癌与非典型髓样癌中E-cadherin、CD44v6的表达及意义[J].肿瘤防治研究,2003,30(2):109-111. |
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| 作者姓名： | 李晓鸣 朱任之 |
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| 作者单位： | 1. 730030,兰州医学院第二附属医院病理科
2. 兰州医学院病理学教研室 |
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| 摘 要： | 目的 探讨乳腺典型髓样癌、非典型髓样癌形态相似而预后差异显著的分子机理。方法 采用免疫组织化学 (s p)法测定 18例乳腺典型髓样癌、30例非典型髓样癌中E cadherin、CD4 4v6的表达。 结果 E cadherin蛋白的表达强度 ,典型髓样癌高于非典型髓样癌 (P <0 .0 5 ) ;非典型髓样癌中CD4 4v6的表达强度明显高于典型髓样癌 (P <0 .0 5 )。结论 E cadherin、CD4 4v6表达的显著差异是乳腺典型髓样癌。
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| 关 键 词： | 乳腺典型髓样癌 非典型髓样癌 免疫组织化学 临床意义 E-cadherin CD44V6 表达 Medullary breast carcinoma E cadherin CD44v6 Immunohistochemistry |
| 文章编号： | 1000-8578(2003)02-0109-03 |
| 收稿时间： | 2002-1-15 |
| 修稿时间： | 2002年1月15日 |
Expression and significance of E-cadherin and CD44v6 in medullary breast carcinoma |
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| LI Xiao ming,ZHU Ren\|zhi.Expression and significance of E-cadherin and CD44v6 in medullary breast carcinoma[J].Cancer Research on Prevention and Treatment,2003,30(2):109-111. |
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| Authors: | LI Xiao ming ZHU Ren\|zhi |
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| Institution: | LI Xiao ming,ZHU Ren\|zhi Department of pathology,Affiliated Hospital of Lanzhou Medical College,Lanzhou 730030,China$$$$ |
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| Abstract: | Objective To study the mechanism of typical medullary carcinoma and atypical medullary carcinoma′s similar morphology and different prognosis . Methods The immunohistochemical staining method was used to evaluate the positivity of E cadhein,CD44v6 in 30 cases of atypicial medullary carcinoma and 18 cases of typicial medullary carcinoma. Results The staining intensity of E cadherin oncoprotein typical medullary carcinoma was significantly higher than those in atypical medullary carcinoma( P <0.05). T... |
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| Keywords: | Medullary breast carcinoma E cadherin CD44v6 Immunohistochemistry |
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