Characterization of a novel HLA-C allele,Cw*0315 |
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Authors: | Chapple S D J Agudelo J D Barnardo M C N M Vargas-Cuero A L Fuggle S V |
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Affiliation: | Transplant Immunology, Oxford Transplant Center, Churchill Hospital, Oxford, UK. |
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Abstract: | The presence of an unusual HLA class I reactivity pattern was detected in a Caucasoid-Asian individual by PCR-sequence specific primer (PCR-SSP) typing. Exons 2 and 3 were characterized using PCR-sequence-based typing (PCR-SBT) and were found to contain a novel Cw*03 sequence, Cw*0315. In the region studied, Cw*0315 was comprised mainly of the Cw*0302 sequence, but at four positions it contained nucleotides normally only found in other HLA Cw locus alleles. These positions each resulted in an amino acid substitution. |
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Keywords: | HLA class I HLA-Cw*0315 PCR-SBT PCR-SSP |
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