尿毒症患者血小板膜糖蛋白Ib含量和血浆vWF浓度变化及意义

对尿毒症患者血小板膜糖蛋白（ＧＰ）Ｉｂ含量用两种不同方法进行测定，同时测定血浆中ｖｏｎ Ｗｉｌｌｅｂｒａｎｄ Ｆａｃｔｏｒ（ｖＷＦ）浓度。结果显示尿毒症组血小板膜ＧＰＩｂ含量显著低于对照组（Ｐ〈０．０１），血透后减少更明显（Ｐ〈０．０５），两种方法测定的血小板膜ＧＰＩｂ减少之间呈正相关（ｒ＝０．５２Ｐ〈０．０１），尿素氮升高与血小板膜ＧＰＩｂ减少无明显相关关系（ｒ＝－０．２Ｐ〉０．０５），血浆中ｖ

THE SIGNIFICANCE AND CHANGE OFPLATELET MEMBRANE GLYCOPROTEIN IB ANDPLASMA VWF CONCENTRATIONS IN UREMIC PA-TIENTS

e studied the platelet GPIb with two methods,vWF were determined in uremic patients.Our resultsshowed the platelet GPIb were decreased in uremia(P<0. 01).Post-dialysis GPIb levels were lower thanpre-dialysis. There was significant positive correlationbetween the platelet GPlb levels used two methods(r= 0. 52,P<0. ol).There was negative correlative be-tween the increment of urea nitrogen and reduction ofplatelet GPIb.The platelet dysfunction was closely re-lated to decrement of platelet GPIb in uremic patients.Platelet hemostatic dysfuntion raise plasma levels ofvWF compensatively.There were toxic metabolicproducts inhibited vWF binding to platelet in blood.