老年人高血压红细胞膜钠和钙离子转运异常与脂质过氧化作用

本文观察40例老年人高血压患者红细胞膜ATP酶活性和红细胞内Na 、Ca 浓度以及血过氧化脂质（LPO）、超氧化物歧化酶（SOD）的变化。结果；老年人高血压红细胞膜Na －K －ATP酶和Ca（2 ）－Mg（2 ）－ATP酶活性明显低于正常组，Na 和Ca（2 ）浓度明显升高，血浆LPO较正常组显著升高，红细胞SOD活性显著下降，并且ATP酶活性的降低与LPO、SOD的改变有显著相关性。提示老年人高血压体内存在钠和钙离子转运障碍，脂质过氧化反应增强及其清除能力减弱可能通过降低ATP酶活性、增加细胞内Ca（2 ）浓度而参与老年人高血压的形成。

The relationship between erythrocytic membrane Na and Ca transportation and lipid peroxidation in the aged hypertensive patient

The changes of erythrocyte ATP ase activity,intraerythrocytic inoic concentration,lipid peroxides(LPO) and superoxide dismutase(SOD) in blood were observed in 40 aged hypertensive patients. The results showed that the Na -K -ATP ase, Ca(2 )-Mg(2 )-ATP ase activity and erythrocyte SOD were significantly lower,Ca(2 ) and Na concentration and plasma LPO were significantly higher in hypertensive patients than in normal individuals. A strong linear relationship was found between decline of ATP ase activity and changes of LPO and SOD. The LPO and Ca(2 ) concentration were positive correlated with mean arterial blood pressure. These findings suggested that the lipid peroxidation,through inhibiting ATP ase activity and increasing intracellular Ca(2 ) concentration,play a important role in the pathogensis of hypertension in the elderly.