休克期切痂对血浆内皮素及NO水平的影响

目的观察烧伤休克期切痂和休克期后切痂对血浆内皮素及一氧化氮水平的影响。方法利用小型猪制成35％Ⅲ度烧伤动物模型,分为两组,休克期切痂组(S组)于伤后24小时切痂,对照组(C组)于伤后96小时切痂,分别检测血浆内皮素(ET)、一氧化氮(NO),并计算ET/NO。结果两组ET及NO均高于伤前,伤后96小时开始S组ET明显低于C组;而NO水平S组明显高于C组;ET/NO亦显示伤后24小时开始S组明显低于C组。结论休克期切痂可减轻内皮细胞损伤,减轻渗出与水肿,减少组织缺氧,改善微循环。

Influence of escharectomy during burn shock stage upon the changes in endothelin and NO

Objective To observe influence of escharectomy during and after burn shock stage upon the changes in plasma ET and NO. Methods 35% TBSA full-thickness burn was produced in pigs, which were divided into two groups. Group S was a group undergoing escharectomy during burn shock stage at 24h postburn. Group C was a group receiving escharectomy at 96h after injury. ET and NO were determined and ET/NO was calculated. Results The levels of ET and NO were higher after injury than before injury in both groups. The level of ET was lower significantly in group S than in group C from 96h postburn on. The level of NO was higher in group S than in group C. The ET/NO was lower in group S than in group C from PBH 24 on. Conclusion Escharectomy during burn shock stage was beneficial in reducing injury of endothelial cells, decreasing exudation and edema, decreasing tissue hypoxia and improving microcirculation.