Comparative pharmacokinetics of sodium- and methylglucamine diatrizoate in urography |
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Authors: | V. Taenzer P. Koeppe K. F. Samwer G. H. Kolb |
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Affiliation: | (1) Klinik für Radiologie, Nuklearmedizin und Physikalische Therapie, Medizinische Klinik und Poliklinik des Klinikum Steglitz der Freien Universität Berlin and Department Biodynamik der Schering AG, Berlin, Germany |
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Abstract: | Summary Comparative tests were carried out, using a radioactive tracer method, on the pharmacokinetics of sodium and methylglucamine diatrizoate. A biological model was simulated using an analogue computer; and the rate and elimination constants, the elimination half life, and the ratio of tissue entry to tissue elimination constants were calculated. Over the period of time required for X-ray diagnosis, the two salts of the contrast medium acid which were tested did not alter the pharmacokinetics of the contrast medium itself. |
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Keywords: | Urography Hypaque® Urovist® pharmacokinetics renal failure |
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