| 缺血性脑卒中患者血浆ET、CGRP和血清 MDA、SOD的测定及其意义 |
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| 引用本文： | 陆建明,马云宝,高雷华. 缺血性脑卒中患者血浆ET、CGRP和血清 MDA、SOD的测定及其意义[J]. 标记免疫分析与临床, 2005, 12(1): 7-9 |
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| 作者姓名： | 陆建明 马云宝 高雷华 |
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| 作者单位： | 1. 扬州大学医学院附属常熟二院神经内科,江苏,常熟,215500
2. 扬州大学医学院附属常熟二院核医学科,江苏,常熟,215500 |
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| 摘 要： | 为探讨缺血性脑卒中患者ET、CGRP及血清MDA、SOD测定的意义, 用放射免疫分析法及TBA比色法测定了患者血浆ET、CGRP及血清MDA、SOD水平.结果提示, 小面积梗死组和大面积梗死组ET水平均显著高于正常对照组(P均小于0.01).两病理组之间比较均存在显著差异(P均小于0.05).大面积组ET与CGRP呈显著负相关(r=-0.668,P＜0.05).MDA及SOD统计值的变化关系与ET、CGRP基本一致.由此认为, 四项指标的变化与脑血管损伤程度关系密切, 其测定有助于判断病情.
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| 关 键 词： | 缺血性脑卒中 内皮素 降钙素基因相关肽 丙二醛 超氧化物歧化酶 |
| 文章编号： | 1006-1703(2005)01-0007-03 |
| 修稿时间： | 2004-04-27 |
Significance of Determination of ET, CGRP, MDA and SOD in Patients with Ischemic Cerebral Apoplexy |
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| LU Jian-ming,MA Yun-bao,GAO Lei-hua. Significance of Determination of ET, CGRP, MDA and SOD in Patients with Ischemic Cerebral Apoplexy[J]. Labeled Immunoassays and Clinical Medicine, 2005, 12(1): 7-9 |
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| Authors: | LU Jian-ming MA Yun-bao GAO Lei-hua |
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| Abstract: | To investigate the clinical significance of determination of ET, CGRP and MDA,SOD in patients with ischemic cerebral apoplexy, plasma ET, CGRP and serum MDA, SOD levels were determined with RIA and TBA.The results showed that ET levels in patients with small and large cerebral infarctions were significantly higher than those in controls(P<0.01), and the levels in patients with large lesions were significantly higher than those in patients with small lesions(P<0.05).In patients with large lesions, the ET level was significantly negatively correlated to the CGRP level.The patterns of change in levels of MDA and SOD were similar to those of ET and CGRP.The imbalance between the two systems was closely related to the severity of cerebrovascular injury.Therefore,determination of their concentrations could help to evaluate the severity of ischemic cerebral apoplexy and its prognosis. |
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| Keywords: | Ischemic cerebral apoplexy ET CGRP MDA SOD |
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