抗血管紧张素Ⅱ1型受体抗体与冠状动脉粥样硬化性心脏病关系研究

目的:探讨抗血管紧张素Ⅱ(AngⅡ)受体1型(AT1受体)自身抗体与冠状动脉粥样硬化性心脏病(冠心病)的关系.方法:80例患者用酶联免疫吸附法检测血清抗AT1受体自身抗体,分为抗AT1受体自身抗体阳性组和抗AT1受体自身抗体阴性组,采用Judkin法作冠状动脉造影检查.结果:46例抗AT1受体自身抗体阳性,34例阴性,在抗AT1受体抗体阳性组中32例冠脉造影至少1支血管狭窄≥50%,抗AT1受体自身抗体阴性组中12例冠脉造影至少1支血管狭窄≥50%,抗AT1受体自身抗体阳性组狭窄病变例数显著高于阴性组(P＜0.01).结论:抗AT1受体自身抗体阳性是冠心病的危险因素之一,对冠心病有一定的预测价值.

Autoantibodies Against AT1-receptor in Patients with Coronary Atherosclerotic Heart Disease

Objective:To explore the role of autoantibodies against AT1-receptor in the development of coronary atherosclerotic heart disease.Method:80 patients with hypertension stage 2 or more were recruited in this study.The epitope of the second extracellular loop of AT1 receptor was synthesized and used as antigens to screen the autoantibodies against AT1receptor by ELISA.All patients accepted selected coronary angiography by the Judkins technique.Result:Narrowing greater than 50% of the luminal diameter of one-,two-,or three-vessel is considered clinically significant.In patients with coronary heart disease,the positive rates of autoantibodies against AT1-receptor were higher than those of patients without coronary heart disease(P<0.01).Conclusion:The findings suggest that the autoantibodies against AT1-receptor may play important roles in the pathogenesis of coronary atherosclerotic heart disease.