正常人群甲状腺自身抗体的临床分析

目的 :研究正常人群甲状腺自身抗体的特点。方法 :运用放射免疫法测定 32 4例正常人、12 5例Graves病 (GD)甲亢患者及 136例桥本甲状腺炎 (HT)甲减患者的甲状腺球蛋白 (TG)、反三碘甲腺原氨酸 (rT3)、游离三碘甲腺原氨酸 (FT3)、游离甲状腺素 (FT4 )、超敏促甲状腺激素 (s TSH)、甲状腺球蛋白抗体 (TGAb)、甲状腺过氧化物酶抗体 (TPOAb)、TSH受体抗体 (TRAb) ,分析正常人群甲状腺自身抗体的特点。结果 :正常人群TGAb、TPOAb、TRAb有一定阳性率 ,分别为 4 .94 % (16 /32 4 )、7.10 % (2 3/ 32 4 )、3.4 0 % (11/ 32 4 ) ,但滴度较低。与GD甲亢及HT甲减患者相比 ,甲状腺抗体阳性的正常人的TGAb、TPOAb、TRAb的滴度明显减低 (P <0 .0 5 )。甲状腺抗体阳性的正常人的TGAb、TPOAb、TRAb的滴度与甲状腺抗体阴性的正常人的TGAb、TPOAb、TRAb滴度相比无明显差异 (P >0 .0 5 )。结论 :正常人群甲状腺自身抗体存在一定阳性率 ,但正常人群所出现的甲状腺抗体无致病作用。

The Clinical Analysis of Thyroid Autoantibodies in Normal Population

Objective:To study the feature of thyroid autoantibodies in normal population. Methods: Serum TG, rT3, FT3, FT4, s TSH, TGAb, TPOAb and TRAb were determined by radioimmunoassay in 324 normal population, 125 patients with Graves' disease in hyperthyroidism, 136 patients with Hashimoto thyroiditis in hypothyroidism. The feature of thyroid autoantibodies in normal population was analyzed. Results: The positive rate in TGAb?TPOAb?TRAb in normal population were 4.94%(16/324), 7.10 %(23/324),3.40%(11/324) respectively. With the titre rather lower. Compared with patients with Graves' disease in hyperthyroidism and those with Hashimoto thyroiditis, the titre of positive thyroid antibodies in normal population was significantly lower ( P <0.05). The titre of thyroid antibodies had no significant difference between normal population with negative thyroid antibodies and those with positive thyroid antibodies ( P >0.05). Conclusion:There were positive rate in thyroid antibodies in normal population, but they had no pathogenic role.