Antibacterial drug discovery and structure-based design |
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Authors: | Barker John J |
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Affiliation: | Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK. john.barker@evotec.com |
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Abstract: | Bacterial resistance continues to develop and pose a significant threat, both in hospitals and, more recently, in the community. A focus on other therapeutic areas by the larger pharmaceutical companies has left a shortfall in the pipeline of novel antibacterials. Recently, many new structures have been studied by structure-genomics initiatives, delivering a wealth of targets to consider. Using the tools of structure-based design, antibacterial discovery must exploit these targets to accelerate the process of drug discovery. |
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