硝苯地平治疗早产的疗效观察

目的:观察硝苯地平对早产的治疗作用及不良反应。方法:将62例妊娠28~36周先兆早产的孕妇随机分为两组,分别口服硝苯地平和沙丁胺醇,观察两组用药后保胎效果、新生儿结局及不良反应。结果:口服硝苯地平后抑制宫缩显效时间为(38.54±11.54)m in,保胎成功率为83.33%,与沙丁胺醇组比较同样有效。主要不良反应为一过性血压降低、潮热、恶心、头痛等,占35.5%(11/31)。结论:硝苯地平治疗早产有效,且无明显不良反应。

Efficacy of Nifedipine in Management of Premature Labor

Objective: To observe the efficacy and side effect of Nifedipine in the management of premature labor.Methods:62 pregnant women with threatened abortion between the 28th and 38th week of pregnancy were randomly assigned to oral Nifedipine administration group and oral Salbutamol administration group.Tocolysis efficacy,outcome of the newborns and the side effects were compared between the two groups.Results:Upon the oral administration of Nifedipine,the time for uterine contraction excellence was prolonged to(38.54 11.54) minutes;the achievement ratio of tocolysis was 83.33%;Nifedipine was as effective as Salbutamol.The side effects of Nifedipine were encountered in 35.5% subjects,mainly including transient hypertension,nausea and headache.Conclusion:Nifedipine was effective as a tocolystic agent in management of premature labor and had few side effects.