| 细菌生物膜：治疗慢性鼻-鼻窦炎的新靶点 |
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| 引用本文： | 程向荣,王秋萍. 细菌生物膜：治疗慢性鼻-鼻窦炎的新靶点[J]. 医学研究生学报, 2008, 21(2): 182-185 |
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| 作者姓名： | 程向荣 王秋萍 |
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| 作者单位： | 南京军区南京总医院耳鼻咽喉科,江苏南京,210002 |
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| 基金项目： | 江苏省自然科学基金资助项目(批准号:BK2006134) |
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| 摘 要： | 慢性鼻-鼻窦炎(CRS)是由致病菌引起的鼻腔鼻窦黏膜的慢性炎症。部分患者对常规抗感染和手术治疗的疗效欠佳。细菌生物膜是细菌自身产生的多聚基质包裹着菌细胞的三维结构群体,因为其对抗生素耐药性极强,成为临床CRS难治性感染的重要原因之一。现将与CRS有关的细菌生物膜的结构及特性、形成发展、抗生素耐药机制、检测手段及防治策略方面的研究进展作一综述,以期寻找有效治疗CRS手段,指导临床合理用药。
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| 关 键 词： | 细菌生物膜 鼻-鼻窦炎 药物治疗 |
| 文章编号： | 1008-8199(2008)02-0182-04 |
| 修稿时间： | 2007-02-27 |
Bacterial biofilm: A new target in the treatment of chronic rhinosinusitis |
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| CHENG Xiang-rong,WANG Qiu-ping. Bacterial biofilm: A new target in the treatment of chronic rhinosinusitis[J]. Bulletin of Medical Postgraduate, 2008, 21(2): 182-185 |
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| Authors: | CHENG Xiang-rong WANG Qiu-ping |
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| Abstract: | Chronic rhinosinusitis(CRS) is a common infectious disease and a subpopulation of patients fail to respond to either medical or surgical intervention.Bacterial biofilms(BBF) are 3-dimensional aggregates of bacteria, which have special properties due to their group structure,including increased resistance to antibiotics in some forms.Evidence suggests that BBF may play an important role in CRS.The goal of this article is to provide an overview of BBF with the special focus on CRS.A further understanding of the role of BBF may lead to the development of more appropriate therapies for CRS. |
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| Keywords: | Bacterial biofilm Rhinosinusitis Drug treatment |
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