红花提取物、羟基红花黄色素A在血瘀大鼠体内的药动学特征

目的研究红花提取物和羟基红花黄色素A（HSYA）在血瘀大鼠体内的药动学特征。方法ItPLC．UV法测定血瘀大鼠血浆中HSYA的血药浓度，应用DAS2．0求得药动学参数。结果红花提取物和HSYA在血瘀大鼠体内主要药动学参数t1/2、ρmax、tmax、AUC0→6h和AuC0→∞分别为（1．38±0．21）和（1．11±0．25）h，（8．05±0．57）和（8．36±1．09）mg·L^-1，（0．75±0．00）和（1．19±0．55）h，（19．24±1．18）和（22．93±2．19）mg·h·L^-1，（20．45±1．00）和（23．84±2．00）mg·h·L^-1.结论红花提取物在急性血瘀大鼠体内吸收比HSYA快，而代谢比HSYA慢，说明红花提取物中其他成分可以影响HSYA的吸收和代谢。

Pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A in blood stasis rats

AIM To study the pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A （HSYA） in blood stasis rats. METHODS The concentrations of HSYA in plasma of blood stasis rats were analyzed by HPLC-UV method. The pharmacokinetic parameters were calculated by the software DAS 2.0. RESULTS The main pharmacokinetic parameterst1/2、ρmax、tmax、AUC0→6h and AuC0→∞of safflor yellow extraction and HSYA were （ 1.38 ±0.21）and （1.11 ±0.25）h, （8.05 ±0.57）and （8.36 ± 1.09）mg·L^-1, （0.75 ±0.00）and（ 1.19 ±0.55）h, （19.24 ±1.18） and （22.93± 2.19） mg· h·L^-1, （20.45± 1.00） and （23.84 ± 2.00） mg· h·L^-1, respectively. CONCLUSION The absorption of safflor yellow is faster than HSYA in acute rat model of blood stasis syndrome , but the metabolism of safflor yellow is evidently slower than HSYA in acute rat model of blood stasis syndrome , which shows that the absorption and metabolism of HSYA could be affected by some factors in sattlor yellow extraction.