Serological follow-up in patients with aorto-iliac disease and evidence of Q fever infection |
| |
Authors: | J C J P Hagenaars N H M Renders A S van Petersen S O A Shamelian M G L de Jager-Leclercq F L Moll P C Wever O H J Koning |
| |
Institution: | 1. Department of Surgery, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, ’s-Hertogenbosch, The Netherlands 2. Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands 3. Department of Surgery, Bernhoven Hospital, Uden, The Netherlands 4. Department of Internal Medicine, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands 5. Department of Internal Medicine, Bernhoven Hospital, Uden, The Netherlands 6. Department of Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands
|
| |
Abstract: | The aim of this study was to provide data on the risk of developing chronic Q fever in patients with aorto-iliac disease and evidence of previous Q fever infection. Patients with an aortic and/or iliac aneurysm or aorto-iliac reconstruction (aorto-iliac disease) and evidence of previous Q fever infection were included. The presence of phase I and II Coxiella burnetii IgG antibodies was assessed periodically using immunofluorescence assay. A total of 111 patients with aorto-iliac disease were divided into three groups, based upon the serological profile mean follow-up: 16?±?9 months (mean?±?standard deviation)]. Group 1 consisted of 30 patients with a serological trace of C. burnetii infection (negative IgG phase I, IgG phase II titer of 1:32). Of these, 36.7 % converted to serological profile matching past resolved Q fever. Group 2 included 49 patients with negative IgG phase I titer and IgG phase II titer ≥1:64. No patients developed chronic Q fever, but 14.3 % converted to a positive IgG phase I titer. Group 3 consisted of 32 patients with positive IgG phase I and positive IgG phase II titers, of which 9.4 % developed chronic Q fever (significantly different from group 2, p?=?0.039). The IgG phase I titer increased in 28.1 % of patients (from 1:64 to 1:4,096). The risk of developing chronic Q fever in patients with aorto-iliac disease and previous Q fever infection with a positive IgG phase I titer was 9.4 %. The IgG phase I titer increases or becomes positive in a substantial number of patients. A standardized serological follow-up is proposed. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|