| 腺苷受体A3:新的抗肿瘤靶点 |
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| 引用本文： | 焦南林,郑杰. 腺苷受体A3:新的抗肿瘤靶点[J]. 国际病理科学与临床杂志, 2006, 26(4): 14-332 |
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| 作者姓名： | 焦南林 郑杰 |
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| 作者单位： | 东南大学基础医学院病理与病理生理学系分子病理研究所,南京,210009 |
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| 摘 要： | 腺苷在一定浓度下对血管形成、免疫逃避、肿瘤生长有很大的影响。腺苷由细胞释放后通过与细胞表面特异性腺苷受体结合对细胞的功能起调节作用。腺苷受体A3（A3 adenosine receptor, A3AR）在腺苷调节细胞活力和生长中起关键作用，并且在很多肿瘤中表达增高，A3AR可能成为肿瘤诊断标志物和治疗靶点。
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| 关 键 词： | 腺苷 腺苷受体A3 肿瘤 |
| 文章编号： | 1673-2588(2006)04-0329-04 |
| 收稿时间： | 2006-04-04 |
| 修稿时间： | 2006-04-04 |
A3 adenosine receptor: A novel target for antitumor therapy |
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| JIAO Nan-lin,ZHENG Jie. A3 adenosine receptor: A novel target for antitumor therapy[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(4): 14-332 |
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| Authors: | JIAO Nan-lin ZHENG Jie |
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| Affiliation: | Institute of Molecular Pathology, Department of Pathology and Pathophysiology, School of Basic Medicine; Southeast University |
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| Abstract: | Adenosine acts as a regulatory molecule through binding to specific cell surface receptors(A_(1),A_(2A),A_(2B),A_(3)).It has a profound impact on the angiogenesis,immunoescaping,and the growth of tumor.Especially,the A_(3) adenosine receptor plays an important role in regulating cell vitality and growth.The overexpression of A_(3) receptors in tumors can potentially be used as a diagnostic marker or a therapeutic target. |
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| Keywords: | adenosine A_(3) adenosine receptor cancer |
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