偏头痛病人血浆同型半胱氨酸水平的变化

目的　探讨同型半胱氨酸与偏头痛关系 ,为偏头痛预防和治疗提供理论依据。方法　对 12 0名偏头痛病人与 40名正常人采用高效液相色谱法和固相免疫放射法测定其血浆同型半胱氨酸、叶酸、维生素B12 浓度 ,比较二者间差异。结果　偏头痛病人血浆同型半胱氨酸水平高于正常对照组 ,分别为 (17.3± 2 .8) μmol/L和 (11 4± 5 .5 ) μmol/L(P <0 .0 1)。而叶酸、维生素B12 浓度较对照组低 (7.8± 4.6 )ng/L ,(431± 15 4.7) pg/L ,(12 .6± 3 .3)ng/L ,(5 0 2± 181.6 ) pg/L],(P >0 .0 5 )。结论　同型半胱氨酸与偏头痛发生有关 ,故对偏头痛病人适当补充叶酸、维生素B12 有益

Change of Plasma Homocysteine in Migraine Patients

Objective To discuss the relation of homocysteine with migraine and provide a theory basis for prevention and treatment. Methods To detect the plasma homocysteine, folic acid, Vitamin B 12 between migraine patients (120) and a control group (40) with HPLC and FPLA mathods, compare the different of two groups. Results The level of homocysteine in migraine group is significative higher than control group, expective 17.3±2.8 μmol/L and 11.4±5.5 μmol/L ( P <0.01). However, The level of folic acid, Vitamin B 12 is lower in migraine group (7.8±4.6 ng/L, 431±154.7 pg/L, 12.6±3.3 ng/L, 502±181.6 pg/L, P >0.05). Conclusion Homocysteine is correlated with migraine occurs, Appropriate supplement folic acid, Vitamin B 12 is necessary for treatment of migraine.