医院获得性脑膜脓毒金黄杆菌所致肺部感染的危险因素及耐药性

目的分析脑膜脓毒金黄杆菌所致肺部感染的危险因素及其耐药性。方法回顾性调查2004年1月-2006年1月医院感染的脑膜脓毒金黄杆菌所致肺部感染60例，对其临床相关资料和体外药敏试验进行分析。结果患者主要分布在重症监护病房（ICU）、呼吸科和神经科病房，均伴有严重基础疾病，气管插管率为56．7％，深静脉留置率为25．0％，留置导尿率为16．7％，使用〉3种抗菌药物的患者占68．3％，该菌耐药现象较为严重，对头孢哌酮／舒巴坦及喹诺酮类抗菌药物等敏感率较高。结论脑膜脓毒金黄杆菌所致肺部感染主要危险因素有严重基础性疾病、侵入性治疗、住院时间长及滥用抗菌药物等，脑膜脓毒金黄杆菌对多种抗菌药物，呈多重耐药性。

Nosocomial Lung Infection by Chryseobacterium meningosepticum:Risk Factors and Drug-resistance

OBJECTIVE To analyze the risk factors and the drug-resistance of nosocomial acquired lung infection by Chryseobacterium meningosepticum.METHODS A retrospective investigation of the clinical correlative data and the drug sensitivity results of 60 cases with nosocomial acquired lung infection by C.meningosepticum from Jan 2004 to Jan 2006 was conducted in local hospital.RESULTS The patients were mainly distributed at ICU,respiration and neurosurgery wards.They had severe underlying diseases(100.0%),tracheal intubation(56.7%),central venous catheter(25.0%) and urine catheter(16.7%) treatments and applications of more than three antibiotics(68.3%).The drug-resistance of C.meningosepticum was serious.The antibiotic drugs which had higher susceptibility ratio were cefoperazone/sulbactam,fluoroquinolones,et al.CONCLUSIONS The main risk factors of nosocomial acquired lung infection by C.meningosepticum are severe underlying diseases,various invasive treatments,long-term hospitalization and inappropriate use of broad spectrum antibiotics.Clinical isolates are multi-drug resistant to many kinds of antibiotics.