Recovery from propofol anaesthesia supplemented with remifentanil |
| |
Authors: | O'Hare R A Mirakhur R K Reid J E Breslin D S Hayes A |
| |
Affiliation: | Department of Anaesthetics and Intensive Care Medicine, The Queens University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK*Corresponding author |
| |
Abstract: | We have examined the effects on recovery end-points of supplementationof a propofol-based anaesthetic with remifentanil. After inductionof anaesthesia with propofol and remifentanil 1.0 µg kg1,15 patients each were randomly allocated to target plasma propofolconcentrations of 2, 3, 4 or 5 µg ml1for maintenance of anaesthesia. Remifentanil was administeredby infusion for supplementation in doses required for maintenanceof adequate anaesthesia. All patients received 50% nitrous oxidein oxygen and ventilation was controlled. The total amount ofdrugs used and times to different recovery end-points were recorded.Cognitive function was also assessed using a Mini-Mental Statequestionnaire. The median dose of remifentanil for maintenanceof adequate anaesthesia (excluding the initial bolus dose) inthe four groups was 0.21, 0.15, 0.11 and 0.13 µg kg1 min1respectively (P=0.0026). The median times to eye opening andorientation were shortest in the 2 µg ml1group [6.0 and 6.5 min, 8.5 and 10.8 min, 13.4 and15.8 min, and 14.2 and 19.5 min respectively in thepropofol 2, 3, 4, and 5 µg ml1 groups respectively(P<0.001)]. The times to discharge from the recovery wardand the Mini-Mental State scores were not significantly different. Br J Anaesth 2001; 86: 3615 |
| |
Keywords: | anaesthesia i.v., propofol analgesics opioid, remifentanil pharmacodynamics |
本文献已被 PubMed Oxford 等数据库收录! |
|