TMA与TGA检测对甲状腺疾病的临床诊断价值

根据174例疑诊患者的TMA、TGA，T3，T4放射免疫测定结果及其临床表现进行诊断，结果表明桥本氏甲状腺炎和甲亢所占的比例(分别为38．51％及31．61％）显著高于甲减和亚急性甲状腺炎(分别为6．32％和4．02％)，P＜0．05。甲减患者TGA TMA的阳性率（81．82％)显著高于甲亢(50．91％)，桥本氏甲状腺炎(50．75％)及亚急性甲状腺炎(57．14％)，P＜0．05。单项抗体阳性者以TMA较TGA为多。本文结果提示在甲状腺疾病中TMA，TGA的阳性结果存在相互重叠现象，与T3、T4联检并结合临床表现进行综合分析有助于甲状腺疾病的鉴别诊断并正确指导治疗。

THE CLINICAL DIAGNOSTIC VALUE OF TMA AND TGA POSITIVENESS IN THYROID DISEASES

In 174 suspected thyroid disease sufferers, diagnosis based on the radioimmu-noassay of serum TMA, TGA, T3, T4 and clinical manifestations revealed that the proportions of Hashimoto thyroiditis and hyperthyroidism(38.51% and 31.61% respectively)were significantly higher than those of hypothyroidism and subacute thyroiditis (6.32% and 4.02% respectively)(p<0.05); and the positive rate of TMA+TGA in hypothyroidism (81.82%) was significantly higher than those in hyperthyroidism (50.91), Hashimoto thyroiditis (50.75%) and subacute thyroiditis (57.14%) (P<0.05),In those cases where only one of TMA and TGA was positive, the positive rate of TMA exceeded that of TGA. The above mentioned results sbaved that positive assays overlapped among the thyroid diseases and correct diagnosis with treatment must be made according to comprehensive analysis along with T3, T4 assay and clinical manifestations.