大脑中动脉闭塞或狭窄缺血性卒中患者血液炎性标志物变化

【摘要】
目的 观察大脑中动脉闭塞（middle cerebral artery occlusion，MCAO）或狭窄的缺血性卒中患者的危险
因素及血白细胞（white blood cell，WBC）、红细胞沉降率（erythrocyte sedimentation rate，ESR）和超敏
C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）的变化。
方法 2005年1月～2011年1月期间北京友谊医院神经内科连续入选符合研究标准的262例缺血性卒中
患者，其中98例MCAO（闭塞组）、23例大脑中动脉（middle cerebral artery，MCA）狭窄率70%～99%（重
度狭窄组）、60例MCA狭窄率50%～69%（中度狭窄组）和81例MCA狭窄率<50%（轻度狭窄组）。比较四
组患者的危险因素及入院24 h血WBC、ESR和hs-CRP等指标。
结果 闭塞组、重度狭窄和中度狭窄组糖尿病患病率明显高于轻度狭窄组（P分别为0.008、0.044和
0.018），其他危险因素在四组间比较差异均无显著性。闭塞组WBC、ESR和hs-CRP水平均高于轻度狭窄
组（P分别为0.005、0.002和0.001）；重度狭窄组ESR亦高于轻度狭窄组（P =0.026）。
结论 MCA闭塞和重度狭窄的缺血性卒中患者血WBC、ESR和hs-CRP水平高于MCA轻度狭窄患者。

Changes of Inflammatory Biomarkers in Ischemic Stroke Patients with Middle Cerebral Artery Occlusion or Stenosis

【Abstract】
Objective To analyze the risk factors and the changes of white blood cell(WBC), erythrocyte
sedimentation rate(ESR) and high-sensitivity C-reactive protein(hs-CRP) in ischemic stroke
patients with middle cerebral artery occlusion(MCAO) and stenosis.
Methods From January 2005 to January 2011, 262 unselected ischemic stroke patients who
were admitted to Department of Neurology in Beijing Friendship Hospital were enrolled into our
study. It included 98 patients with MCAO(MCAO group), 23 patients with 70%~99% stenosis
in middle cerebral artery(MCA)(severe stenosis group), 60 patients with 50%~69% stenosis in
MCA(moderate stenosis group), and 81 patients with less 50% stenosis in MCA(mild stenosis
group). The risk factors and WBC, ESR and hs-CRP in 24 h after admission were compared among
four groups.
Results The proportion of history of diabetes mellitus in the MCAO group, severe stenosis group
and moderate stenosis group was significantly higher than that in the mild stenosis group(P =0.008,
0.044, 0.018), There were no significant differences in other risk factors among the four groups.
WBC, ESR and hs-CRP levels in the MCAO group was significant higher than those in the mild
stenosis group(P =0.005, 0.002, 0.001). The level of ESR in the severe stenosis group was also
significantly higher than that in the mild stenosis group(P =0.026).
Conclusion WBC, ESR and hs-CRP levels elevated in stroke patients with occlusion and severe
stenosis in MCA.