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| 炎症与脑出血的靶向治疗 | |
| 引用本文： | 刘晓静,张拥波,李继梅. 炎症与脑出血的靶向治疗[J]. 中国卒中杂志, 2013, 0(4): 272-276 |
| 作者姓名： | 刘晓静 张拥波 李继梅 |
| 作者单位： | 100050.北京;首都医科大学附属北京;友谊医院神经内科 |
| 摘 要： | 【摘要】 炎症在脑出血后继发性脑损伤过程中起关键作用，涉及胶质细胞、血管内皮细胞以及基 质金属蛋白酶（matrix metalloproteinases，MMP）、肿瘤坏死因子（tumor necrosis factor，TNF）-α、白 介素（interleukin，IL）及补体等多种炎症细胞及因子。目前对脑出血仍缺乏有效的治疗药物。针对脑出 血后炎症反应的治疗方法主要包括环氧化酶(cyclooxygenase，COX）抑制剂、MMP抑制剂、血管紧张素1 （angiotensin1，AT1）受体阻滞剂、他汀类药物、干细胞移植等，可能为脑出血的治疗提供新的靶点。 |
| 关 键 词： | 脑出血 损伤机制 炎症细胞 炎性因子 治疗 |
| 收稿时间： | 2012-12-06 |
Inflammation as Therapeutic Target of Intracerebral Hemorrhage |
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| LIU Xiao-Jing,ZHANG Yong-Bo,LI Ji-Mei.. Inflammation as Therapeutic Target of Intracerebral Hemorrhage[J]. Chinese Journal of Stroke, 2013, 0(4): 272-276 | |
| Authors: | LIU Xiao-Jing ZHANG Yong-Bo LI Ji-Mei. |
| Affiliation: | Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China |
| Abstract: | 【Abstract】 The mechanisms of brain damage induced by cerebral hemorrhage are complicated. Inflammation plays an important role in the secondary process of brain damage. It involves a lot of inflammatory cells and mediators. There are few treatments of cerebral hemorrhage. We conclude the potential drugs which target the inflammatory process during cerebral hemorrhage. |
| Keywords: | Cerebral hemorrhage Damage mechanism Inflammatory cells Inflammatory mediators Treatment |
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