Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment |
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Authors: | Jessica Rodrigues Brazè te,Jacques Montplaisir,Dominique Petit,Ronald B. Postuma,Josie-Anne Bertrand,Daphné Gé nier Marchand,Jean-Franç ois Gagnon |
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Affiliation: | 1. Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada;2. Department of Psychology, Université de Montréal, Montreal, Quebec, Canada;3. Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada;4. Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada;5. Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada |
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Abstract: | BackgroundIdiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a well-documented risk factor for synucleinopathies such as Parkinson disease (PD) and dementia with Lewy bodies (DLB). Moreover, approximately 50% of iRBD patients have mild cognitive impairment (MCI). The purpose of our study was to investigate waking electroencephalogram (EEG) abnormalities specific to iRBD patients with MCI.MethodsForty-two polysomnographically confirmed iRBD patients, including 23 iRBD [+]MCI patients 19 patients without MCI (iRBD [−]MCI), and 37 healthy subjects participated in the study. All participants underwent a complete neuropsychologic assessment for MCI diagnosis and a waking quantitative EEG recording.ResultsiRBD [+]MCI patients had a higher slow-to-fast frequency ratio than iRBD [−]MCI patients and controls in the parietal, temporal, and occipital regions. iRBD [+]MCI patients also had higher relative θ power in the parietal, temporal, and occipital regions and lower relative α power in the occipital region compared to iRBD [−]MCI patients and controls. Moreover, iRBD [+]MCI patients had higher relative θ power in the frontal and central areas and lower relative β power in the central, parietal, and temporal regions compared to controls. The dominant occipital frequency also was slower in iRBD [+]MCI patients compared to controls. No between-group differences were observed between iRBD [−]MCI patients and controls.ConclusionIn iRBD patients, only those with concomitant MCI showed waking EEG slowing in the posterior cortical regions, providing a potential marker for an increased risk for developing DLB or PD. |
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Keywords: | REM sleep behavior disorder Electroencephalography Spectral analysis Mild cognitive impairment Parkinson&rsquo s disease Dementia with Lewy bodies |
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