| 肿瘤标志物神经特异性烯醇化酶与糖链抗原125及血清细胞角蛋白19片段和癌胚抗原在肺癌诊断与分期中的价值 |
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| 引用本文： | 徐一凯,陈素珍,胡丹丹,王世强,章潜,楼黎明. 肿瘤标志物神经特异性烯醇化酶与糖链抗原125及血清细胞角蛋白19片段和癌胚抗原在肺癌诊断与分期中的价值[J]. 中国临床保健杂志, 2017, 20(5): 498-501 |
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| 作者姓名： | 徐一凯 陈素珍 胡丹丹 王世强 章潜 楼黎明 |
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| 作者单位： | 1.浙江中医药大学附属第三医院呼吸科 |
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| 基金项目： | 浙江省中医药科技计划项目(2016ZA111) |
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| 摘 要： | 目的探讨肿瘤标志物神经特异性烯醇化酶(NSE)、糖链抗原125(CA125)、血清细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)的检测在肺癌诊断与分期中的应用价值。方法选择确诊的65例肺癌患者,设为肺癌组;65例肺部良性疾病患者,设为良性组;65例同期健康体检者,设为对照组。统计血清肿瘤标志物[CYFRA21-1、CA125、NSE、CEA]检出水平;统计肺癌组不同病理分型CYFRA21-1、CA125、NSE、CEA的检出情况;统计各肿瘤标志物单独诊断及联合诊断肺癌的敏感性、特异性及准确度。结果肺癌组CYFRA21-1、CA125、NSE、CEA水平为(15.49±4.52)μg/L、(88.80±14.17)μg/L、(43.51±9.17)μg/L、(10.87±4.33)μg/L,明显高于良性组的(3.85±1.82)μg/L、(22.16±4.12)μg/L、(12.38±3.44)μg/L、(4.01±1.12)μg/L(P<0.05),且明显高于小细胞癌组的(1.32±0.52)μg/L、(13.11±1.68)μg/L、(5.19±2.11)μg/L、(1.04±0.54)μg/L(P<0.05);良性组CYFRA21-1、CA125、NSE、CEA血清浓度明显高于对照组(P<0.05)。腺癌组CA125、CEA水平为(192.46±9.67)μg/L、(19.15±3.28)μg/L,明显高于鳞癌组的(38.86±8.82)μg/L、(7.33±1.78)μg/L(P<0.05),且明显高于小细胞癌组的(41.66±8.45)μg/L、(6.21±1.29)μg/L(P<0.05);腺癌组CYFRA21-1、NSE水平为(6.28±1.22)μg/L、(22.85±4.19)μg/L,明显低于鳞癌组(26.33±6.19)μg/L、(32.65±7.12)μg/L(P<0.05),且明显低于小细胞癌组(9.25±2.84)μg/L、(89.62±11.37)μg/L(P<0.05);鳞癌组CYFRA21-1血清浓度高于小细胞癌组(P<0.05),NSE血清浓度低于小细胞癌组(P<0.05)。联合检测CYFRA21-1、CA125、NSE、CEA的敏感性和准确度为91.75%、94.87%,分别高于单独检测值。结论 CYFRA21-1、CA125、NSE、CEA等肿瘤标志物水平在肺癌患者血清中异常增高,单独检测可辅助诊断肺癌以及进行病理分型,联合检测能提高肺癌早期诊断的准确度和敏感性。
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| 关 键 词： | 肺肿瘤 抗原 肿瘤相关 碳水化合物 角蛋白19 癌症早期检测 |
| 收稿时间： | 2017-06-26 |
Value of tumor markers CYFRA21-1,NSE and CEA in the diagnosis and staging of lung cancer |
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| Xu Yikai,Chen Suzhen,Hu Dandan,Wang Shiqiang,Zhang Qian and Lou Liming. Value of tumor markers CYFRA21-1,NSE and CEA in the diagnosis and staging of lung cancer[J]. Chinese Journal of Clinical Healthcare, 2017, 20(5): 498-501 |
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| Authors: | Xu Yikai Chen Suzhen Hu Dandan Wang Shiqiang Zhang Qian Lou Liming |
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| Affiliation: | Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China,Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China,Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China,Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China,Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China and Respiratory Medicine Department of Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China |
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