| 血脂康与他汀类药物调脂效果对比及安全性分析 |
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| 引用本文： | 徐智超,唐海沁,张亚文,徐迎春,陈洁霞.血脂康与他汀类药物调脂效果对比及安全性分析[J].中国临床保健杂志,2017,20(1):28-32. |
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| 作者姓名： | 徐智超 唐海沁 张亚文 徐迎春 陈洁霞 |
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| 作者单位： | ;1.安徽医科大学第一附属医院老年心血管科 |
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| 基金项目： | 国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015133) |
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| 摘 要： | 目的评价血脂康与常见他汀类降脂药物对原发性高脂血症疗效。方法计算机检索Pub Med、Cochrane图书馆、万方医学数据库、维普中文科技期刊全文数据库,筛选关于中药血脂康与他汀类药物治疗原发性高脂血症随机对照实验。评价指标包括胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。采用Revman5.3软件进行分析。结果实验共纳入14篇文献,共计1150例患者,结果血脂康、他汀类药物均明显降低原发性高脂血症患者TC、TG、LDL-C,明显升高HDL-C,但Meta分析提示血脂康与他汀类药物对原发性高脂血症患者降低血TC、TG、LDL-C疗效差异无统计学意义WMD=0.01mmol/L,95%CI:(-0.05~0.07)mmol/L,P0.05;WMD=0.07 mmol/L,95%CI:(-0.26~0.41)mmol/L,P0.05;WMD=0.13 mmol/L,95%CI:(-0.44~0.69)mmol/L,P0.05],对升高患者血高密度脂蛋白疗效差异无统计学意义WMD=0.13 mmol/L,95%CI:(-0.44~0.69)mmol/L,P0.05]。结论血脂康与他汀类药物均可降低原发性高脂血症患者血TC、TG、LDL-C,升高血HDL-C,两者疗效相当,血脂康致不良反应更少,安全性更高。
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| 关 键 词： | 降血脂药物 高脂血症 Meta分析 |
| 收稿时间： | 2016/3/8 0:00:00 |
Comparison of effectiveness and safety between Xuezhikang and statins for hyperlipidemia |
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| Xu Zhichao,Tang Haiqin,Zhang Yawen,Xu Yingchun and Chen Jiexia.Comparison of effectiveness and safety between Xuezhikang and statins for hyperlipidemia[J].Chinese JOurnal of Clinical Healthcare,2017,20(1):28-32. |
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| Authors: | Xu Zhichao Tang Haiqin Zhang Yawen Xu Yingchun and Chen Jiexia |
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| Institution: | Department of Geriatrics Cardiovascular,the First Affiliate Hospital of Anhui Medical University,Hefei 230022,China,Department of Geriatrics Cardiovascular,the First Affiliate Hospital of Anhui Medical University,Hefei 230022,China,Department of Geriatrics Cardiovascular,the First Affiliate Hospital of Anhui Medical University,Hefei 230022,China,Department of Geriatrics Cardiovascular,the First Affiliate Hospital of Anhui Medical University,Hefei 230022,China and Department of Geriatrics Cardiovascular,the First Affiliate Hospital of Anhui Medical University,Hefei 230022,China |
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