老年隐性高血压患者中心动脉压及增强指数与脉搏波传导速度的相关性

目的探讨老年隐性高血压(MH)患者中心动脉压(CAP)及增强指数(AI)与脉搏波传导速度(PWV)的相关性,为完善老年MH患者的诊疗方案提供参考。方法选择健康体检人群170例,根据《中国高血压防治指南》将其分为高血压组55例、MH组50例、对照组(血压正常)65例。观察比较三组受检者一般资料、动态血压及偶测血压情况、颈-桡动脉PWV与CAP参数。结果 MH组饮酒、吸烟、低密度脂蛋白胆固醇(LDL-C)及空腹血糖显著高于对照组(P<0.05)。MH组偶测舒张压与收缩压高于高血压组(P<0.05)。MH组颈-桡动脉PWV、AI、血压第一峰值与最小血压差(P1 Height)、增强压、收缩末压(CESP)、平均舒张压(CMDP)、平均收缩压(CMSP)、脉压(CPP)、舒张压(DBP)、收缩压(SBP)显著高于对照组(P<0.05)。颈-桡动脉PWV与LDL-C、CPP与SBP、体质量指数、TC、年龄、空腹血糖、DBP、P1 Height、CESP、AI及增强压呈正相关(P<0.05)。LDL-C、CPP及SBP为颈-桡动脉PWV的主要影响因素。结论老年MH患者CAP明显高于血压正常者,PWV明显升高。LDL-C、CPP及SBP增高为颈-桡动脉PWV的危险因素。

Correlation between central aortic pressure and augmentation index and pulse wave velocity in elderly patients with masked hypertension

Objective To investigate the elderly masked hypertension (MH) patients with central arterial pressure (CAP) and augmentation index (AI) and pulse wave velocity (PWV) correlation,and to provide a reference for improving the diagnosis and treatment of elderly patients with MH.Methods According to the guidelines for prevention and treatment of hypertension in China,170 cases of healthy people were selected and divided into hypertension group (55 cases),MH group (50 cases) and control group (65 cases with normal blood pressure).The general data of the 3 groups were observed and compared with those of ambulatory blood pressure and even blood pressure,carotid radial artery PWV and CAP parameters.Results MH group of drinking,smoking,low density lipoprotein cholesterol (LDL-C) and fasting blood glucose were significantly higher than those of control group (P<0.05).Systolic and diastolic blood pressure of MH group were higher than those of hypertension group(P<0.05).MH group of carotid radial artery PWV,AI,blood pressure and blood pressure difference between the first peak minimum (P1 Height),increased pressure,end systolic pressure (CESP) and mean diastolic blood pressure (CMDP),average systolic blood pressure (CMSP),pulse pressure (CPP),diastolic blood pressure (DBP) and systolic blood pressure (SBP) were significantly higher than those of the control group (P<0.05).PWV and CPP,SBP,TC,age,fasting blood glucose,DBP,Height,P1,CESP and enhanced pressure were positively correlated with LDL-C and AI (P<0.05).LDL-C,CPP and SBP were the main influencing factors of cervical radial artery PWV (P<0.05).Conclusion CAP in elderly patients with MH is significantly higher than that of normal blood pressure,PWV is significantly increased.The increased LDL-C,CPP and SBP are the high risk factors of carotid radial artery PWV.