| 干燥综合征患者肺功能与血小板活化之间的关系 |
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| 引用本文： | 刘健,章平衡,万磊,黄旦,黄传兵,张晓军,孙玥,刘磊.干燥综合征患者肺功能与血小板活化之间的关系[J].中国临床保健杂志,2017,20(6):652-654. |
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| 作者姓名： | 刘健 章平衡 万磊 黄旦 黄传兵 张晓军 孙玥 刘磊 |
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| 作者单位： | ;1.安徽中医药大学第一附属医院风湿科 |
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| 基金项目： | 国家自然基金青年项目(81403388);安徽省自然基金项目(1508085QH159);安徽省高校自然科学基金重点项目(KJ2017A281)；安徽省重点实验室资助项目(1606c08238) |
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| 摘 要： | 目的探讨干燥综合征患者肺功能与血小板活化之间的关系。方法选取干燥综合征患者66例设为观察组,同时选取健康体检者30例设为对照组。采用肺功能仪检测患者肺功能,流式细胞术检测外周血血小板分化抗原CD40配体(CD40L)表达,魏氏法检测血小板(PLT),ELISA试剂盒检测血小板活化因子(PAF)、血小板α颗粒膜糖蛋白-140(GMP-140)、血小板源性生长因子(PDGF)的水平。结果与对照组相比较,观察组肺功能参数明显降低,PLT、PAF、GMP-140、PDGF、CD40L水平明显升高(P<0.05);在观察组患者中,肺功能降低的40例,占所有病例的60.61%,肺功能异常率最高为75%肺活量位的最大呼气流量(FEF_(75)),其次是FEV1/FVC、50%肺活量位的最大呼气流量(FEF_(50))、25%肺活量位的最大呼气流量(FEF_(25))、呼气峰流速值(PEF)。与不伴肺功能降低的SS组比较,伴肺功能降低的观察组的PLT、PAF、PDGF水平明显升高(P<0.05)。相关性分析显示:SS患者FEV1/FVC与PDGF呈负相关,FEF_(25)与CD40L呈负相关(P<0.01),FEF_(50)与PAF、GMP-140呈负相关(P<0.05,P<0.01),FEF_(75)、PEF与PLT呈负相关(P<0.05,P<0.01)。结论干燥综合征患者存在肺功能降低,且肺功能降低与血小板活化及其活化产物的水平密切相关。
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| 关 键 词： | 干燥综合征 呼吸功能试验 血小板活化 |
| 收稿时间： | 2017/6/16 0:00:00 |
Relationship between platelet activation and lung function in patients with sjogren's syndrome |
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| Liu Jian,Zhang Pingheng,Wan Lei,Huang Dan,Huang Chuanbing,Zhang Xiaojun,Sun Yue and Liu Lei.Relationship between platelet activation and lung function in patients with sjogren's syndrome[J].Chinese JOurnal of Clinical Healthcare,2017,20(6):652-654. |
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| Authors: | Liu Jian Zhang Pingheng Wan Lei Huang Dan Huang Chuanbing Zhang Xiaojun Sun Yue and Liu Lei |
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| Institution: | Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China,Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China and Department of Rheumatology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China |
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