Cardiovascular risk markers in pregnancies complicated by diabetes mellitus or preeclampsia |
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| Authors: | Meryam Sugulle Florian Herse Marleen Seiler Ralf Dechend Anne Cathrine Staff |
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| Institution: | 1. Departments of Obstetrics and Gynaecology, Oslo University Hospital, Ullevål, P.O. Box 4956 Nydalen, 0424 Oslo, Norway;2. Experimental and Clinical Research Center, a Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany;3. B.R.A.H.M.S Biomarkers, Clinical Diagnostics Division, Thermo Fisher Scientific, 16761 Hennigsdorf, Germany;4. HELIOS Clinic, 13125 Berlin, Germany;5. Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, 0316 Oslo, Norway;1. Gastroenterology Hospital Maresca, Torre del Greco, Italy;2. Gastroenterology Hospital Curto, Polla, Italy;3. Gastroenterology ACO San Filippo Neri, Roma, Italy;4. Medical Department, Bracco, Milano, Italy;1. Department of Urology, University of Miami, Miami, FL, USA;2. Interdisciplinary Stem Cell Institute, University of Miami, Miami, FL, USA;3. Department of Medicine, University of Miami, Miami, FL, USA;4. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;5. Department of Pathology, University of Miami, Miami, FL, USA;1. Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland;2. Department of Neonatology, University Hospital Zurich, Zurich, Switzerland;3. Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland;4. Division of Neonatology, University Children''s Hospital Basel, Basel, Switzerland;5. Institute for Experimental Endocrinology, Charité University Medical Center, Berlin, Germany;1. Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan;2. Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;3. Department of Animal Science, Tokyo University of Agriculture, Kanagawa, Japan;3. Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom;;4. Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust and Institute of Human Development, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom;;5. Women''s Health Academic Centre, King''s College London and King''s Health Partners, London, United Kingdom;;6. Department of Obstetrics and Gynaecology, Auckland University, Auckland, New Zealand;;12. Department of Obstetrics & Gynaecology, University of Adelaide, Adelaide, Australia |
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| Abstract: | ObjectiveTo explore biomarkers indicating cardiovascular disease in pregnant women with diabetes or preeclampsia, since these women are at increased risk for future cardiovascular disease.Study designEDTA-plasma from 262 women in gestational week 24–42 (healthy pregnancies n = 71, preeclampsia n = 105, type 2 diabetes n = 17, gestational diabetes n = 61, diabetes with preeclampsia n = 8) was analyzed by immunoassay for neopterin, midregional pro-adrenomedullin (MR-proADM) and C-terminal pro-arginine vasopressin (CT-proAVP). The diabetes groups were also analyzed for midregional pro-atrial natriuretic peptide (MR-proANP), and compared to previously reported MR-proANP concentrations for healthy, normotensive and preeclamptic patients.ResultsIn contrast to preeclampsia, median plasma MR-proANP was not increased in pregnancies complicated by diabetes, but in fact lower, compared to healthy pregnancies. Neopterin was increased in diabetic pregnancies and in late onset preeclampsia, compared to healthy pregnancies. Median plasma MR-proADM was increased in pregnancies complicated by gestational diabetes or preeclampsia, compared to healthy pregnancies. Median plasma MR-proANP was increased in diabetic pregnancies complicated by preeclampsia compared to pregnant women with diabetes only.ConclusionWomen with pregnancies complicated by diabetes mellitus or preeclampsia are at risk for future cardiovascular disease, but differ in circulating cardiovascular biomarker profile. A cardiovascular biomarker profiling during pregnancy might prove helpful in identifying women at risk for future cardiovascular disease, thus enabling targeted prophylactic interventions and follow-up. |
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