Antibacterial activities of some Indian traditional plant extracts |
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| Authors: | N Prasannabalaji G Muralitharan RN Sivanandan S Kumaran SR Pugazhvendan |
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| Affiliation: | 1. Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappali 620 024, Tamilnadu, India;2. Department of Medical Biotechnology, Sri Ramachandra University, Porur, Chennai 600 116, Tamilnadu, India;3. CAS Marine Biology, Annamalai University, Parangipettai 608 502, Tamilnadu, India;4. Department of Zoology, DDE, Annamalai University, Annamalai Nagar 608 002, Tamilnadu, India;1. Bio industry and Food Technology team. Agri-Food and Food Safety Laboratory. Sidi Mohamed Ben Abdallah University, Imouzzer Road, Fez 30000, Morocco;2. Institute of Nursing Professions and Health Techniques of Fez, Regional Direction of Health, El Ghassani Hospital, Fez 30000, Morocco;3. Department of Biology, Faculty of Science and Technology Al-Hoceima. Ajdir 32003. Abdelmalek Essaâdi University, Tetouan, Morocco;1. Universidad de Antofagasta, Departamento de Ciencias de los Alimentos y Nutrición, FACSA, Angamos 601, Antofagasta, Chile;2. Universidad de Antofagasta, Laboratorio Química Biológica, Instituto Antofagasta and Departamento de Química, Angamos 601, Antofagasta, Chile;3. Universidad de Antofagasta, Departamento de Biotecnología, FACIMAR, Angamos 601, Antofagasta, Chile;4. Universidad de Antofagasta, Departamento de Tecnología Médica, FACSA, Angamos 601, Antofagasta, Chile;5. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile;6. Universidad Diego Portales, Laboratorio de Productos Bioactivos, Facultad de Medicina, Santiago, Chile |
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| Abstract: | ObjectiveTo evaluate the in vitro antibacterial activity of various solvent extracts of South Indian traditional medicinal plants Ocimum sanctum, Ocimum gratissimum, Aegle marmelos, and Adhatoda vasica leaves against clinical pathogens of human origin.MethodsThe antimicrobial activity of different solvents crude extract of four medicinal plants used in traditional Indian medicine was tested by disc diffusion method against five bacterial pathogens: Escherichia coli, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi and klebsiella pneumoniae.. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was determined for evaluating the potential plant extract.ResultsThe antibacterial results showed methanol extracts (0.4 g/ml) of Ocimum gratissimum and Ocimum sanctum showed maximum zone of inhibition (30 mm and 25.5 mm, respectively) against Salmonella typhi. MIC was tested at various concentrations from 0.625 mg/ml to 0.039 mg/ml for all the plant extracts. At the lowest concentration (0.039mg/ml) tested, methanol extracts of Ocimum gratissimum showed higher MIC against Salmonella typhi and Salmonella paratyphi where as the methanolic extracts of Ocimum gratissimum showed potent activity against Staphylococcus aureus at 0.078 mg/ml. Methanol extract (0.4 g/ml) of Aegle marmelos showed significant inhibitory activity of 22.5mm and MIC value of 0.156.mg/ml against E. coli strain. The Klebsiella spp was the most resistant strain of all and various concentrations Adhatoda vasica extract showed less activity against the tested pathogens.ConclusionsThe present screening result demonstrated that the Indian traditional medicinal plants Ocimum sanctum, Ocimum gratissimum, Aegle marmelos methanol leaf extract has potent antibacterial activity and the studied plants may be new source for novel antibacterial compound discovery for treating drugs resistant human pathogens. |
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