孕妇血清生物素水平与胎儿生长及早产的相关性分析

目的　探究孕妇血清生物素水平与胎儿生长及早产的相关性。方法　选取铜川市人民医院自2019年1月~10月收治的90例孕妇为观察组。另选取同期该院体检健康且未怀孕女性90例作为对照组。观察组根据妊娠时期的不同分为早、中、晚期妊娠。观察组根据妊娠结局的不同分为足月儿组、早产儿组和小于胎龄儿（Substantial gainful activity，SGA）组，比较足月儿组、早产儿组和SGA组的平均年龄、身体质量指数(Body Mass Index, BMI)和初产。通过酶联免疫吸附法(ELISA)检测外周血血清和脐带血血清中生物素的水平，采用Pearson 相关分析探究生物素水平与胎儿生长及早产的相关性。结果　妊娠孕妇血清中生物素水平在妊娠初期至晚期保持较低水平，且显著低于对照组(F=14.39，P<0.001)。足月儿组脐带血血清中生物素水平高于早产儿组和SGA组，其组间差异具有统计学意义(F=70.387，P<0.001)。足月儿组外周血血清中生物素水平高于早产儿组和SGA组，其组间差异不具有统计学意义(F=1.294，P=0.279)。足月儿组、早产儿组和SGA组脐带血血清中生物素水平高于外周血，其差异均具有统计学意义(t=4.214~12.188，均P<0.001)。Pearson 相关分析结果显示血清中生物素水平与胎儿胎龄呈正相关关系(r=0.32，P=0.01)。结论　怀孕期间孕妇可适当补充生物素以预防胎儿生长的异常。

Analysis of Correlation between Serum Biotin Level and Fetal Growth and Premature Delivery in Pregnant Women

Objective To explore the correlation between serum biotin level and fetal growth and premature delivery in pregnant women.Methods A total of 90 pregnant women admitted to the Tongchuan People’s Hospital from January to October 2019 were included in the observation group.In addition,90 healthy and non-pregnant women in the hospital were selected as the control group.The observation group was divided into early,middle and third trimesters according to different gestation periods.According to different pregnancy outcomes,the observation group was divided into the term infants group,the premature infants group and the SGA group,and the mean age,Body Mass Index(BMI)and the first delivery of the term infants,the premature infants group and the SGA group were compared.Biotin levels in peripheral blood serum and cord blood serum were detected by enzyme-linked immunosorbent assay(ELISA),and Pearson correlation analysis was used to explore the correlation between biotin levels and fetal growth and premature delivery.Results The serum biotin level of pregnant women remained low from the first trimester of pregnancy and was significantly lower than that of the control group(F=14.39,P<0.001).The serum biotin level in the full-term infant group was higher than that in the premature infant group and the SGA group,and the difference between the two groups was statistically significant(F=70.387,P<0.001).The serum biotin level in the peripheral blood of the term infant group was higher than that of the premature infant group and SGA group,and the difference between the two groups was not statistically significant(F=1.294,P=0.279).Biotin levels in cord blood were higher in the term infant group,premature infant group and SGA group than in peripheral blood,and the difference were statistically significant(t=4.214~12.188,all P<0.001).Pearson correlation analysis showed that serum biotin level was positively correlated with fetal gestational age(r=0.32,P=0.01).Conclusion During pregnancy,pregnant women may take appropriate biotin supplements to prevent abnormal fetal growth.