NLR和LMR对EGFR-TKIs治疗EGFR突变阳性非小细胞肺癌预后的预测价值

目的:探讨治疗前血清中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)和淋巴细胞与单核细胞比值(lympho cyte to monocyte ratio,LMR)对表皮生长因子受体-酪氨酸激酶抑制剂(epidermal growth factor receptor-tyr...

The predictive value of NLR and LMR for the prognosis of non-small cell lung cancer harboring EGFR mutations treated with epidermal growth factor receptor-tyrosine kinase inhibitors

Objective:To investigate the predictive value of pretreatment serum neutrophil-to-lymphocyte ratio(NLR)and lymphocyte-to-monocyte ratio(LMR)for the prognosis of non-small cell lung cancer(NSCLC)harboring EGFR mutations treated with epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs).Methods:We retrospectively analyzed 112 cases of stageⅣNSCLC patients harboring EGFR mutations who received EGFR-TKIs.The patients were divided into two groups(high group and low group)with appropriate cutoff point using the receiver operating characteristic(ROC)curve method.The progression free survival(PFS)and overall survival(OS)between different groups were compared.Multivariate analysis was used to identify independent prognostic factor for PFS and OS.Results:According to the ROC curve,the appropriate cutoff point of NLR and LMR were 2.92 and 3.81 respectively.PFS in the low NLR group was significantly longer than PFS in the high NLR group(15.6 vs 10.5 months,P<0.001),OS in the low NLR group was significantly longer than in the high NLR group(26.9 vs 19.3 months,P=0.003).PFS in the high LMR group was longer than PFS in the low LMR group(13.4 vs 11.5 months,P=0.024),OS in the high LMR group was longer than in the low LMR group(26.2 vs 21.8 months,P=0.020).Multivariate analysis found that ECOG scores and pretreatment NLR were independent prognostic factor of PFS and OS.Conclusion:Pretreatment serum NLR level can be used as a predictor of prognosis in stageⅣNSCLC patients harboring EGFR mutations who received EGFR-TKIs.