Pilot study of salivary butyrylcholinesterase,phosphodiesterase, thiols and cerulopalsmin in auditory neuropathy |
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| Authors: | Krishnananda Prabhu Kailesh Poojari Bhavya Prabhu Rimshida Malik Anjali Rao |
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| Institution: | 1. Department of Biology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey;2. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova 35131, Italy;3. DAFNAE, Department of Agronomy, Food, Natural Resources, Animals and Environment, Agripolis Campus, University of Padova, Legnaro, PD 35020, Italy;4. Department of Biotechnology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey;5. Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius;6. Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam;7. Faculty of Environment and Chemical Engineering, Duy Tan University, Da Nang 550000, Vietnam;8. Indigenous Knowledge Systems Centre, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho, North West Province 2745, South Africa;1. Suzhou Municipal Hospital, Suzhou Affiliated Hosptial of Nanjing Medical University, Suzhou, Jiangsu 215001, China;2. Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China;3. Department of Toxicology and Function Assessment, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China;4. Institute of Occupational Disease Prevention, Jiangyin Municipal Center for Disease Control and Prevention, Jiangyin, Jiangsu 214434, China |
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| Abstract: | ObjectiveTo estimate butyrylcholinesterase (BChE), phosphodiesterase (PDE), thiols and cerulopalsmin by non – invasive means in saliva a of subjects (both cases and controls) and correlated to their hearing sensitivity.MethodsTotal of 13 subjects participated in this study. Among them 7 were having auditory neuropathy and 6 were healthy controls. Unstimulated saliva (10 ml) was collected from each participant. Ceruloplasmin, thiols, phosphodiesterase and pseudocholinesterase were estimated by colorimetric method in the salivary samples.ResultsSalivary BChE and PDE levels were marginally elevated and protein thiols were marginally decreased in cases as compared to that of controls. Salivary ceruloplasmin was significantly decreased (p = 0.022) in cases as compared to that of controls.ConclusionsSaliva can be used as a potential noninvasive tool for evaluation of disorders. |
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