Hepatoprotective activity of Spillanthes acmella Extracts against CCl4-induced liver toxicity in rats |
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| Authors: | B. Ganga Rao Y. Venkateswara Rao T. Mallikarjuna Rao |
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| Affiliation: | 1. Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, China;2. Guilin Medical University, Guilin 541004, China;3. Department of Physiology, Guilin Medical University, Guilin 541004, China;1. Department of Neurology, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325027, China;2. Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;2. Department of pediatrics, Institute of Neurology; Tianjin Children''s Hospital; No. 225, Tianjin, China |
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| Abstract: | ObjectiveHepato protective activity of Spillanthes acmella Extracts (70% ethanol, methanol, ethyl acetate and hexane) were investigated.MethodsHepatoprotective activity was assessed against CCl4 induced liver intoxication.ResultsThe extracts were produced concentration dependent percentage protection in the reduction of enzymes (Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase, Alkaline phasphatase and Total bilirubin) levels against CCl4 induced liver intoxication in rats. Among all extracts methanol extract showed better activity compare to other extracts with percentage protection of SGOT (84.39%), SGPT (79.04%), ALP (78.15%) and Total bilirubin (80.00%) levels at a dose of 500mg/kg.ConclusionsFrom the results obtained during the present study it could be concluded that Spillanthes acmella extracts has components that have hepato protective effects. |
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