Intellectual functioning of childhood leukemia survivors - relation to Tau protein - a marker of white matter injury |
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| Authors: | M Krawczuk-Rybak A Grabowska PT Protas K Muszynska-Roslan A Holownia J Braszko |
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| Institution: | 1. Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland;2. Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland;1. Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland;2. Department of Molecular Biology and Medical Genetics, Medical University of Silesia, Sosnowiec, Poland;3. Clinical Department of Internal Diseases, Dermatology and Allergy, Medical University of Silesia, Zabrze, Poland;2. Department of Epidemiology. Medical University of Silesia, Katowice, Poland;3. Canadian Centre for Health and Safety in Agriculture. University of Saskatchewan, Saskatoon, Canada;1. Department of General and Visceral Surgery, Asklepios Hospital Barmbek, Hamburg, Germany;2. Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany;3. Fraunhofer-MeVis Institute for Visualization, University of Bremen, Bremen, Germany;1. The Centre for Tick-borne Diseases, Budapest, Hungary;2. Semmelweis University, Budapest, Hungary;3. Faculty of Veterinary Science, Szent István University, Budapest, Hungary;1. Department of Pediatrics, Gastroenterology and Allergology, Medical University of Bialystok, Bialystok, Poland;2. Department of Clinical Immunology, Medical University of Bialystok, Bialystok, Poland |
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| Abstract: | PurposeChemo- and radiotherapy used in acute lymphoblastic leukemia (ALL) can influence on brain functioning in the future. In a prospective study we analysed the cognitive functions of ALL survivors in relation to Tau protein as a marker of white matter injury.Material and methodsThirty-one survivors of childhood ALL (6.3 years after diagnosis); without the signs of CNS involvement, treated with chemotherapy alone, rested in first remission; underwent Intelligence tests- Wechsler Intelligence Scales (WISC-R, WAIS-R). Their results were analyzed in relation to the levels of Tau in cerebrospinal fluid (CSF) obtained during the treatment.ResultsThe analysis showed that all survivors attained the average scores in intelligence tests. A negative correlation was found between methotrexate (MTX) doses and Freedom from Distractibility (FFD). Females had higher values of Performance Intelligence Quotient (PIQ) than males. A negative correlation was noted of Tau protein levels obtained from the last CSF with: Total and Verbal Intelligence Quotient, PIQ, Perceptual Organisation Index and FFD but not with Verbal Comprehension Index.ConclusionOur results suggest the possibility of white matter injury during the treatment for ALL with chemotherapy alone. Elevated Tau protein level in CSF at the end of treatment might indicate future difficulties in neurocognitive functioning. |
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