Hepatoprotective activity of Mentha arvensis Linn. leaves against CCL4 induced liver damage in rats |
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| Authors: | Kalpana Patil Alka Mall |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, Faculty of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar, J&K, India, 193201;2. Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi, India, 110062;1. Department of Biotechnology, Sathyabama University, Jeppiaar Nagar, Chennai-600119;2. Deparment of Bio-organic laboratory, Central Leather Research Institute, Adyar, Chennai |
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| Abstract: | ObjectiveTo study the Hepatoprotective activity of ethanol, chloroform and aqueous extracts of Mentha arvensis leaves against CCL4 induced liver damage in rats.MethodsHepatotoxicity was induced by CCL4 and the biochemical parameters such as serum glutamate pyruvate transminase (sGPT), serum glutamate oxaloacetate transaminase (sGOT), alkaline phosphatase (sALP), serum bilirubin (sB) and histopathological changes in liver were studied along with silymarin as standard Hepatoprotective agents.ResultsThe Phytochemical investigation of the extracts showed presence of flavonoids, steroids, triterpenoids, alkaloids, glycosides, carbohydrates, tannins, phenolic compounds. Treatment of the rats with chloroform, ethanol and aqueous extract with CCL4 administration caused a significant reduction in the values of sGOT, sGPT, sALP and sB (P < 0.01) almost comparable to the silymarin. The Hepatoprotective was confirmed by histopathological examination of the liver tissue of control and treated animals.ConclusionsFrom the results it can be concluded that Mentha arvensis possesses Hepatoprotective effect against CCL4 induced liver damage in rats. |
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