Protocol for the Observation of the Primo Vascular System in the Lymph Vessels of Rabbits |
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Authors: | Sharon Jiyoon Jung Sang Yeon Cho Kyoung-Hee Bae Sun Hee Hwang Byung-Cheon Lee Sungchul Kim Byoung Se Kwon Hee Min Kwon Yoon-Kyu Song Kwang-Sup Soh |
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Institution: | 1. Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon, Republic of Korea;2. Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Republic of Korea;3. Yonsei Institute of Convergence Technology, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon, Republic of Korea;4. National Cancer Center, Goyang, Republic of Korea;5. Ki Primo Research Laboratory, Division of Electrical Engineering, KAIST Institute for Information Technology Convergence, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea;6. Department of Acupuncture & Moxibustion, Gwangju Medical Center, Wonkwang University, GwangJu, Republic of Korea |
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Abstract: | Molecular-level understanding of the structure and the functions of the lymphatic system has greatly enhanced the importance of this second circulation system, especially in connection with cancer metastasis and inflammation. Recently, a third circulatory system, the primo vascular system (PVS) was found in various parts of an animal's body, especially as threadlike structures floating in the lymphatic flow in lymph vessels. Although the medical significance of this emerging system will require much work in the future, at present, several important suggestions in connection with immune cells, stem cells, and cancer metastasis have already appeared. Experiments to observe the PVS in the lymph vessels near the caudal vena cava of rabbits and rats have been performed by several independent teams, but reproduction requires considerable skill and technical know-how. In this article, we provide a detailed protocol to detect the PVS inside the lymph vessels of a rabbit. Detection and isolation are the first steps in unraveling the physiological functions of the PVS, which awaits intensive research. |
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