Lipid concentration in small for gestational age (SGA)pregnancies and hypertensive disorders |
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| Authors: | Saeideh Ziaei Shahideh Jahanian Anoshirvan Kazemnejad |
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| Institution: | 1. Department of Obstetrics and Gynaecology, University of British Columbia, BC, Canada;2. Department of Medicine, University of British Columbia, BC, Canada;3. Child & Family Research Institute, University of British Columbia, BC, Canada;4. Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand;5. Department of Medicine, University of Otago, Christchurch, New Zealand;1. Robinson Research Institute, University of Adelaide, Adelaide, Australia;2. Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;3. Adelaide Medical School, University of Adelaide, Adelaide, Australia;4. Department of Obstetrics and Gynaecology, Lyell McEwin Hospital, Elizabeth Vale, Australia;5. Epidemiology Branch, SA Health, Adelaide, Australia;1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;2. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;3. Department of Pathophysiology, Tonji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, MetroHealth Medical Center–Case Western Reserve University, Cleveland, OH;2. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL |
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| Abstract: | ObjectiveLow maternal serum lipid and high maternal serum lipid have both been associated with some complications in pregnancy. The lipid profiles in pregnancies complicated by small for gestational age (SGA) or hypertension disorders have been compared with those of normal pregnancies.MethodIn a prospective study, 900 pregnant women between 13 and 23 weeks of pregnancy were studied. Primarily, serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, were measured. Ultimately, the serum lipid levels at 13–23 weeks of pregnancies were compared between the women who later suffered from hypertension disorders or SGA and the matched women with normal pregnancies.ResultsAt 13–23 weeks of pregnancy, the mean triglyceride levels were significantly higher in the women who later experienced preeclampsia when compared with normal, matched pregnancies with an appropriate weight for gestational age and women who had gestational hypertension (p = 0.001 and p = 0.014, respectively). Also, triglyceride levels were significantly higher in women with neonates with large for gestational age (LGA) in comparison with those who gave birth to neonates with SGA (p = 0.012) and with uncomplicated matched pregnant women who gave birth to neonates with weight >10th and <90th percentile for their gestational age (p = 0.007).ConclusionOnly the levels of TG and not any other lipids evaluated were found to be different in pregnancies complicated by preeclampsia when compared to pregnancies complicated by SGA. |
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