In vitro antidiabetic activity of psidium guajava leaves extracts |
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| Authors: | Sabjan Khaleel Basha Vinoji Sugantha Kumari |
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| Institution: | 1. Department of Biochemistry, C. Abdul Hakeem College, Melvisharam-632 509, India;2. Department of Chemistry, Auxilium College, Vellore-632 006, India;1. Department of Biochemistry, Dr Lankapalli Bullayya P G College, Visakhapatnam-530013, AP, India;2. Department of Bioinformatics, GIS, GITAM University, Visakhapatnam-530045, AP, India;1. Young Researchers Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;2. Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran;1. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy St., Cairo 11562, Egypt.;2. Pharmaceutical Department, Heliopolis Academy, Sekem, 3 Cairo-Belbeis Road, El Horreya, Cairo, Egypt, P.B. 2834.;3. Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology and Montreal Diabetes Research Centre, Université de Montréal, Montreal, Quebec, Canada H3 C3J7 |
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| Abstract: | ObjectiveTo evaluate the glucose uptake of (antidiabetic activity) crude n-hexane, ethanol, ethanol and aqueous leaf extracts of P. guajava.MethodsP. guajava leaf extracts were subjected to inhibitory effect of glucose utilization using specific standard in vitro procedure.ResultsResults in four different leaf extracts revealed that, the methanol extract at a concentration of 50g plant extract/l was found to be more potent than other extracts with the lowest mean glucose concentration of 201+1.69 mg/dl at the end of 27 hrs.ConclusionsThe present findings suggest that, the methanolic extract showed a significant inhibitory effect on glucose diffusion in vitro thus validating the traditional claim of the plant. |
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