Health benefits of high-density lipoproteins in preventing cardiovascular diseases |
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| Authors: | Hicham Berrougui Claudia N. Momo Abdelouahed Khalil |
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| Affiliation: | 1. Research Centre on Aging, Sherbrooke University Geriatric Institute, 1036 rue Belvedere south, Sherbrooke, QC, Canada J1H 4C4;2. Department of Biology, University Sultan Moulay Slimane, Beni-Mellal, Morocco;1. Academic Assembly, Institute of Agriculture, Shinshu University, Minamiminowa, Nagano 399-4598, Japan;2. Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, Minamiminowa, Nagano 399-4598, Japan;3. Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Minamiminowa, Nagano 399-4598, Japan;4. Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Nagano 390-8621, Japan;1. U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization, Bio-oils Research Unit, 1815 N. University Street, Peoria, IL, 61604, USA;2. U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization, Functional Foods Research Unit, 1815 N. University Street, Peoria, IL, 61604, USA;3. Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; National Engineering Lab. for Biomass Chemical Utilization; Key Laboratory on Forest Chemical Engineering, SFA; Key Laboratory of Biomass Energy and Material of Jiangsu Province, Nanjing, Jiansu, 210042, China;4. College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, 450001, China;5. Shandong Fuyang Biotechnology Co, Pingyuan, Shandong, 253100, China;1. State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China;2. School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China;3. School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China;4. International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China;1. Editor-in-Chief, The Journal of Clinical Lipidology, Charles Howard Candler Professor of Internal Medicine Emeritus, Emory University School of Medicine, 1670 Clairmont Road, Atlanta, GA 30033, USA;2. Medical Director and President, Louisville Metabolic and Atherosclerosis Research Center Inc., 3288 Illinois Avenue, Louisville, KY 40213, USA;3. Chief Science Officer, Biofortis Clinical Research, Addison, IL, USA;4. Professor and Chief, Gynecology, Clinical Epidemiology, and Preventive Cardiology, Oklahoma University Health Sciences Center, Veterans Medical Center, Oklahoma City, OK, USA |
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| Abstract: | Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL is a more desirable target than simply increasing HDL-cholesterol levels. The best known antiatherogenic function of HDL particles relates to their ability to promote reverse cholesterol transport from peripheral cells. However, HDL also possesses antioxidant, anti-inflammatory, and antithrombotic effects. This review focuses on the state of knowledge regarding assays of HDL heterogeneity and function and their relationship to cardiovascular diseases. |
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