奥氮平与齐拉西酮对精神分裂症患者血清催乳素、瘦素及糖脂代谢指标的影响

目的 对比分析奥氮平与齐拉西酮对精神分裂症患者血清瘦素、催乳素及糖脂代谢指标的影响,为优化临床治疗方案提供依据.方法 前瞻性选取2018年1月至2019年12月咸阳市中心医院精神科收治的60例首发精神分裂症患者作为研究对象,采用随机数字表法将患者分为奥氮平组和齐拉西酮组,每组各30例.奥氮平组患者给予口服奥氮平片治疗,...

Effects of olanzapine and ziprasidone on serum prolactin,leptin,glucose and lipid metabolism in patients with schizophrenia

Objective To compare the effects of olanzapine and ziprasidone on serum leptin,prolactin,glucose and lipid metabolism in patients with schizophrenia so as to provide basis for optimizing clinical treatment.Methods The 60 patients with first-episode schizophrenia admitted to the Department of Psychiatric,Xianyang Central Hospital from January 2018 to December 2019 were selected as the research objects,30 cases were included into each group.The patients in the olanzapine group were treated with olanzapine tablet,the patients in the ziprasidone group were treated with ziprasidone hydrochloride capsules.The treatment courses of the two groups were no less than 6 weeks.The positive and negative syndrome scale(PANSS)score,the clinical global impressions-severity of illness scale(CGI-S)score,the fasting blood glucose(FBG),the fasting insulin(INS),the glycosylated hemoglobin(HbA1c),the triglyceride(TG),the total cholesterol(TC),the low-density lipoprotein cholesterol(LDL-C),the high-density lipoprotein(HDL-C),the serum prolactin,the serum leptin levels before treatment and at 6th week after treatment between the patients in the two groups were compared and analyzed.Results The PANSS score,the positive symptom score,the negative symptom score,the general psychopathology score and CGI-S score between the patients in the two groups at 6th week after treatment were significantly lower than those before treatment,the differences were statistically significant(P<0.05).There was no statistically significant difference in the above scores between the two groups before and after treatment(P<0.05).There was no statistically significant difference in glucose and lipid metabolism indexes and serum prolactin,leptin levels between the two groups before treatment(P>0.05).At 6th week after treatment,the levels of FBG,INS,HbA1c,TG,TC,LDL-C,prolactin and leptin levels of the patients in the olanzapine group were higher than those before treatment,while TG,TC,LDL-C,prolactin and leptin levels of the patients in the ziprasidone group were higher than those before treatment,the differences were statistically significant(P<0.05).The levels of FBG,INS,HbA1c,TG,TC,LDL-C,prolactin and leptin levels of the patients in the ziprasidone group were lower than those in the olanzapine group,the differences were statistically significant(P<0.05).Conclusion In the treatment of first-episode schizophrenic patients,the application of olanzapine or ziprasidone has almost the same curative effects,but ziprasidone has less influence on the indexes of glucose and lipid metabolism,serum prolactin and leptin levels.The adverse reactions of metabolic abnormalities are mild and the application has higher safety.