局部晚期鼻咽癌患者治疗前外周血乳酸脱氢酶/白蛋白比例与预后的相关性

目的:回顾性分析局部晚期鼻咽癌患者治疗前外周血中乳酸脱氢酶/白蛋白比例(lactate dehydrogen-ase to albumin ratio,LAR)与患者治疗后预后的相关性.方法:收集2014年06月至2018年12月之间收治入院的296例初治Ⅲ/Ⅳa,b期(AJCC第7版分期)鼻咽癌患者为研究对象,采用外...

The correlation between peripheral lactate dehydrogenase to albumin ratio and prognosis in patients with locally advanced nasopharyngeal carcinoma

Objective:To evaluate the predictive value of peripheral blood lactate dehydrogenase to albumin ratio(LAR)in patients with locally advanced nasopharyngeal carcinoma(NPC).Methods:A total of 296 patients withⅢ/Ⅳ_a,b(AJCC 7th edition)nasopharyngeal carcinoma(NPC),who admitted in hospital between June 2014 to December 2018 were enrolled.We employed a threshold of pretreatment LAR=3.633(median)to stratify patients.The association between pretreatment LAR and curative effect before treatment and its effects on distant metastasis-free survival(DMFS),local recurrence-free survival(LRFS)and overall survival(OS)were analyzed.Results:HighLAR(≥3.633)was associated with advanced age(P=0.000)and deaths(P=0.000).Cox multivariate regression model showed that high LAR was an independent inferior prognostic factor for OS,LRFS,DMFS.Conclusion:Pretreatment LAR is an independent prognostic factor in locally advanced nasopharyngeal carcinoma and could be used in risk stratification and guiding adjuvant therapy.