Cardiovascular Side Effect Remotely Related to NSAIDs: A Comparative Experimental Study on Albino Rats |
| |
| Authors: | R Niranjan R Manik AK Srivastava G Palit SM Natu |
| |
| Institution: | 1. Department of Anatomy, Govt medical college, Haldwani (U.A.);1. The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science & Technology, Wuhan, 430081 PR China;2. Zhengzhou Huite Group Co., Ltd, Zhengzhou, 452370 PR China;1. Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses, Physicochimiques et Biologiques. Université frères Mentouri, Constantine, Route de Ain El Bey-25000, Constantine, Algeria;2. Equipe de Chimie Analytique des Molécules Bioactives, Faculté de Pharmacie, 74, route du Rhin, 67401, Illkirch, Cedex, France;1. Department of Anesthesia, Stanford University School of Medicine, Stanford, California;2. Department of Anesthesia, Santa Clara Valley Hospital, San Jose, California;1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran;2. Institute of Science, High Technology, and Environmental Sciences, Graduate University of Advanced Technology, 76315117 Kerman, Iran;3. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;4. Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran;5. Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan 84156-83111, Iran;6. Center of Excellence in Sensors and Green Chemistry, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran;7. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;1. National Centre for Macromolecular Hydrodynamics, University of Nottingham, Sutton Bonington LE12 5RD, UK;2. Insulin and Diabetes Experimental Research (IDER) Group, University of Nottingham, Faculty of Medicine and Health Science, Clifton Boulevard, Nottingham NG7 2RD, UK;3. Abant Izzet Baysal University, Department of Food Engineering, 14280 Bolu, Turkey;4. Glycomix Ltd, Science and Technology Centre, Earley Gate, Whiteknights Road, Reading RG6 6BZ, UK;5. Factors Group R&D, 3655 Bonneville Place, Burnaby, BC V3N 4S9, Canada;6. University of British Columbia, Food, Nutrition and Health Program, Vancouver, BC V6T 1Z4, Canada;7. Division of Food Sciences, University of Nottingham, Sutton Bonington LE12 5RD, UK;1. Laboratorio de Invertebrados Bentónicos, Unidad Académica Mazatlán, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Apdo. Postal 811, Mazatlán, Sinaloa 82000, Mexico;2. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (CSIC), Jordi Girona 18, 08034 Barcelona, Spain |
| |
| Abstract: | Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit enzyme cyclo-oxygenase (COX)-1&2, required for antiinflammatory effect, which comes along with side effect of gastric ulceration related to inhibition of COX-1. Whereas recent NSAIDs act selectively on COX-2 isoform. Thus referred as selective NSAIDs. Therefore selective NSAIDs are more beneficial than earlier non-selective NSAIDs in regard of incidence of gastric ulceration. Metabolism of these drugs is associated with liver and kidney. Therefore, we observed the comparative adverse effects of diclofenac sodium (diclo) a non-selective NSAIDs and valdecoxib (valde), a selective NSAIDs on renal function. The experiment was carried on 50 albino rats of duckrey (DR) strain, in equal sex ratio. Animals were divided into five groups (n=10). Group A, B1, B2, C1 & C2. Group A served as control, B1 & B2 were given diclo 5 & 10 mg/kg/day per orally, C1 & C2 were given valde 1 & 2 mg/kg/day per orally respectively, for 30 days. Renal histological examination and biochemical parameters were estimated. We estimated serum creatine, blood urea nitrogen (BUN), uric acid (UA), Na+ & K+ for renal function. Kidney sections of all the groups showed thickening of glomerular basement membrane, increase in glomerular cellularity, and degeneration of proximal and distal convoluted tubule. Tubule in medulla showed degeneration with intraluminal protein exudates. Histopathological changes were more significant with valdecoxib. In biochemical estimation lower dose of diclo showed increase in serum K+ only, on other hand lower dose of valde showed more significant change and there was increase in serum creatine, BUN & K+. Whereas higher doses of diclo and valde showed highly significant increase in serum creatine, BUN & K+. Increased UA was observed only with higher dose of valde. Thus these result show renal insufficiency, fluid overload and accumulation of urea & K+. These can lead to congestive heart failure, pericarditis, hypertension, arrhythmias. Thus, chronic renal failure patient suffers from accelerated atherosclerosis and high incidence of cardiovascular disease can be explained. Valdecoxib though banned due to cardiovascular effects and atherosclerosis which can also linked indirectly from renal insufficiency. |
| |
| Keywords: | NSAIDs renal insufficiency cardiac insufficiency |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
